Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, China; Institute of Chinese Medicine, Guangdong Pharmaceutical University; Guangdong TCM Key Laboratory for Metabolic Diseases, Guangzhou 510006, China.
Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine; Key Laboratory of Glucolipid Metabolic Disorder, Ministry of Education of China, China.
Biomed Pharmacother. 2023 May;161:114545. doi: 10.1016/j.biopha.2023.114545. Epub 2023 Mar 20.
The public health issue of glucolipid metabolic disorders (GLMD) has grown significantly, posing a grave threat to human wellness. Its prevalence is rising yearly and tends to affect younger people. Metaflammation is an important mechanism regulating body metabolism. Through a complicated multi-organ crosstalk network involving numerous signaling pathways such as NLRP3/caspase-1/IL-1, NF-B, p38 MAPK, IL-6/STAT3, and PI3K/AKT, it influences systemic metabolic regulation. Numerous inflammatory mediators are essential for preserving metabolic balance, but more research is needed to determine how they contribute to the co-morbidities of numerous metabolic diseases. Whether controlling the inflammatory response can influence the progression of GLMD determines the therapeutic strategy for such diseases. This review thoroughly examines the role of metaflammation in GLMD and combs the research progress of related therapeutic approaches, including inflammatory factor-targeting drugs, traditional Chinese medicine (TCM), and exercise therapy. Multiple metabolic diseases, including diabetes, non-alcoholic fatty liver disease (NAFLD), cardiovascular disease, and others, respond therapeutically to anti-inflammatory therapy on the whole. Moreover, we emphasize the value and open question of anti-inflammatory-based means for treating GLMD.
糖脂代谢紊乱（GLMD）这一公共卫生问题日益严重，严重威胁着人类健康。其发病率逐年上升，且趋于年轻化。代谢相关性炎症是调控机体代谢的重要机制，通过涉及 NLRP3/caspase-1/IL-1、NF-κB、p38MAPK、IL-6/STAT3、PI3K/AKT 等多条信号通路的复杂多器官串扰网络，影响全身代谢调控。众多炎症介质对于维持代谢平衡至关重要，但尚需更多研究来明确其在多种代谢性疾病共病中的作用。调控炎症反应是否能影响 GLMD 的进展，决定了此类疾病的治疗策略。本文深入探讨了代谢相关性炎症在 GLMD 中的作用，并梳理了相关治疗方法的研究进展，包括炎症因子靶向药物、中药（TCM）和运动疗法。整体而言，多种代谢性疾病，包括糖尿病、非酒精性脂肪性肝病（NAFLD）、心血管疾病等，对抗炎治疗均有反应。此外，我们强调了基于抗炎的 GLMD 治疗方法的价值和存在的问题。
