Masaki N, Hashimoto T, Ikeda H, Inoue T, Kozuka T
Department of Radiology, Osaka University Medical School, Japan.
Jpn J Clin Oncol. 1987 Dec;17(4):303-7.
During the 15 years from 1967 to 1981, 3,162 patients with carcinoma of the head and neck were treated with radiation therapy. Among them, 262 patients (8.3%) developed two or more independent malignancies. There were 80 patients with prior cancer. The overall incidence of second malignancies in patients who had radiation therapy was 5.8%. The incidences were 8.9, 7.7, 5.2 and 1.7% of index cancer in the larynx, pharynx, oral cavity and paranasal sinus, respectively. Second primaries were observed in the head and neck (36%), digestive tract (35%), lung (19%) and the remaining 10% in other bodily sites. Of the 1,486 patients who survived for five years or more after radiation therapy, only 10 (0.7%) developed second malignancies within the previous radiation field.
在1967年至1981年的15年间，3162例头颈部癌患者接受了放射治疗。其中，262例患者（8.3%）发生了两种或更多种独立的恶性肿瘤。有80例患者曾患过癌症。接受放射治疗的患者中第二原发性恶性肿瘤的总体发生率为5.8%。在喉、咽、口腔和鼻窦的索引癌患者中，发生率分别为8.9%、7.7%、5.2%和1.7%。第二原发性肿瘤见于头颈部（36%）、消化道（35%）、肺（19%），其余10%见于身体其他部位。在放射治疗后存活五年或更长时间的1486例患者中，只有10例（0.7%）在先前的放射野内发生了第二原发性恶性肿瘤。
