Boddie A W, Goepfert H, Fischer E P, Ballantyne A J
Laryngoscope. 1977 Dec;87(12):2090-5. doi: 10.1288/00005537-197712000-00015.
Second primary tumors develop in up to 20% of patients with reticuloendothelial malignancies (REM). At the M. D. Anderson Hospital between 1944 and 1975, there were 29 patients with pre-existing reticuloendothelial malignancies who developed second primary tumors of the head and neck. The presence of pre-existing REM complicated staging of the head and neck lesion in 14 of 29 cases (48%). In patients with clinically palpable nodes the status of involvement was correctly assessed in only 4 of 14 instances (28%). Though only 3 of 29 patients (10%) survived for 5 or more years, the average survival from diagnosis of head and neck cancer to last follow-up or death was 31 months. Patients with REM in conjunction with head and neck melanoma or with squamous carcinoma of the facial skin or lip had an average survival of 20.7, 40.3, and 51.3 months respectively. Patients with REM in conjunction with second primaries involving the oral cavity, nasal, or oral pharynx, hypopharynx, or larynx did poorly with an average survival of only 8.5 months.
在高达20%的网状内皮系统恶性肿瘤（REM）患者中会发生第二原发性肿瘤。1944年至1975年期间，在MD安德森医院，有29例患有先前存在的网状内皮系统恶性肿瘤的患者发生了头颈部第二原发性肿瘤。在29例病例中的14例（48%）中，先前存在的REM使头颈部病变的分期变得复杂。在临床上可触及淋巴结的患者中，在14例中有4例（28%）正确评估了受累情况。虽然29例患者中只有3例（10%）存活了5年或更长时间，但从诊断头颈部癌症到最后一次随访或死亡的平均生存期为31个月。患有REM并伴有头颈部黑色素瘤、面部皮肤或唇部鳞状癌的患者，平均生存期分别为20.7个月、40.3个月和51.3个月。患有REM并伴有累及口腔、鼻腔、口咽、下咽或喉部的第二原发性肿瘤的患者预后较差，平均生存期仅为8.5个月。
