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镓扫描显示粒细胞集落刺激因子相关性主动脉炎。

Granulocyte Colony-stimulating Factor-associated Aortitis on Gallium Scintigraphy.

机构信息

Department of Medical Oncology, Toranomon Hospital, Japan.

Department of Cardiology, Toranomon Hospital, Japan.

出版信息

Intern Med. 2023 Nov 1;62(21):3163-3166. doi: 10.2169/internalmedicine.1453-22. Epub 2023 Mar 22.

Abstract

Aortitis is a rare adverse event associated with granulocyte colony-stimulating factor (G-CSF). Contrast-enhanced computed tomography (CECT) is widely used to diagnose G-CSF-associated aortitis. However, the usefulness of gallium scintigraphy for the diagnosis of G-CSF-associated aortitis is unknown. We herein report a set of pre- and post-treatment gallium scintigrams of a patient with G-CSF-associated aortitis. During the diagnosis, gallium scintigraphy revealed hot spots on the arterial walls that appeared inflamed on CECT. Both the CECT and gallium scintigraphy findings disappeared. Gallium scintigraphy can be a supportive diagnostic tool for G-CSF-associated aortitis, especially in patients with an impaired renal function or allergy to iodine contrast.

摘要

巨细胞动脉炎是一种与粒细胞集落刺激因子(G-CSF)相关的罕见不良事件。增强计算机断层扫描(CECT)被广泛用于诊断 G-CSF 相关性巨细胞动脉炎。然而,镓闪烁显像术对 G-CSF 相关性巨细胞动脉炎的诊断价值尚不清楚。本文报告了一例 G-CSF 相关性巨细胞动脉炎患者的治疗前后镓闪烁显像结果。在诊断过程中,镓闪烁显像显示动脉壁上有热点,在 CECT 上显示炎症。CECT 和镓闪烁显像的发现均消失。镓闪烁显像术可作为诊断 G-CSF 相关性巨细胞动脉炎的辅助手段,特别是在肾功能受损或对碘造影剂过敏的患者中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2101/10686721/f3f6ff2cef08/1349-7235-62-3163-g001.jpg

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