Department of Inflammation Biology, Centre for Nephrology, Urology and Transplantation, School of Immunology and Microbial Sciences, King's College London, London, UK.
Department of Inflammation Biology, Centre for Nephrology, Urology and Transplantation, School of Immunology and Microbial Sciences, King's College London, London, UK.
Kidney Int. 2023 Apr;103(4):658-660. doi: 10.1016/j.kint.2022.12.020.
Borderline allograft rejection can promote acute rejection and graft loss in some, but not all, patients. In this issue, Cherukuri et al. use a novel test based on peripheral blood transitional T1 B cells producing interleukin-10 and tumor necrosis factor-α, which identifies patients at high risk for poor outcomes. The potential mechanisms by which transitional T1 B cells might modulate alloreactivity need exploration, but following appropriate validation, this biomarker could risk stratify patients in need of early intervention.
边缘型移植物排斥反应可在部分（而非全部）患者中促进急性排斥反应和移植物丢失。在本期杂志中，Cherukuri 等人采用了一种基于外周血中转的 T1B 细胞产生白介素-10 和肿瘤坏死因子-α的新型检测方法，该方法可识别发生不良结局的高危患者。需要进一步研究转的 T1B 细胞调节同种异体反应的潜在机制，但在经过适当验证后，该生物标志物有望对需要早期干预的患者进行风险分层。
