男性生殖与衰老。

Male Reproduction and Aging.

机构信息

Division of Endocrinology and Metabolism, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI 541, Boston, MA 02115, USA; Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.

Division of Endocrinology and Metabolism, Brigham and Women's Hospital, Harvard Medical School, 221 Longwood Avenue, BLI 541, Boston, MA 02115, USA; Northwestern Medicine McHenry Hospital, Chicago Medical School, Rosalind Franklin University of Medicine and Science, McHenry, IL, USA.

出版信息

Endocrinol Metab Clin North Am. 2023 Jun;52(2):211-228. doi: 10.1016/j.ecl.2022.12.002. Epub 2023 Feb 16.

DOI:10.1016/j.ecl.2022.12.002

PMID:36948776

Abstract

Recent publications of well-conducted population studies have informed us that the syndromic prevalence of age-related low testosterone, also known as late-onset hypogonadism, is quite low. Several well-conducted trials in middle-aged and older men with age-related decline in testosterone levels have revealed that efficacy of testosterone therapy is modest with improvement in sexual function, mood, volumetric bone density, and anemia. Although select older men might benefit from testosterone therapy, its effect on prostate cancer risk and major adverse cardiovascular events remains unclear. The results of the ongoing TRAVERSE trial will likely provide important insights into these risks.

摘要

最近发表的一些精心设计的人群研究告诉我们，与年龄相关的低睾酮症（也称为迟发性性腺功能减退症）的综合征患病率相当低。几项精心设计的针对中年和老年男性、与睾酮水平下降相关的试验表明，睾酮治疗的疗效是适度的，可改善性功能、情绪、容积骨密度和贫血。虽然某些老年男性可能受益于睾酮治疗，但它对前列腺癌风险和主要不良心血管事件的影响仍不清楚。正在进行的 TRAVERSE 试验的结果可能会为这些风险提供重要的见解。