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性别与药理学之间的关系。

The relationship between gender and pharmacology.

作者信息

Younes Samer

机构信息

Department of Pharmacy, Tartous University, Syria.

出版信息

Curr Res Pharmacol Drug Discov. 2024 Jun 18;7:100192. doi: 10.1016/j.crphar.2024.100192. eCollection 2024.

Abstract

The part of sexuality in pharmacology research was not acknowledged, and it was not thought-out to be a determinant that could impact strength and disease. For decades research has mainly contained male, women and animals, leading to a lack of news about syndromes in females. Still, it is critical to guarantee equal likeness so that determine the security, influence, and resistance of healing agents for all individuals. The underrepresentation of female models in preclinical studies over various decades has surpassed to disparities in the understanding, disease, and treatment of ailments 'tween genders. The closeness of sexuality bias has happened recognized as a contributing determinant to the restricted interpretation and replicability of preclinical research. Many demands operation have stressed the significance of including sexuality as a organic changeable, and this view is acquire growing support. Regardless of important progress in incorporating more female models into preclinical studies, differences prevail contemporary. The current review focuses on the part of sexuality and common in biomedical research and, therefore, their potential function in pharmacology and analyze the potential risks guide.

摘要

药理学研究中性别因素未得到认可,也未被视为可能影响疗效和疾病的决定因素。几十年来,研究主要涉及男性、女性和动物,导致缺乏关于女性综合征的信息。然而,确保平等代表性对于确定治疗药物对所有个体的安全性、有效性和耐受性至关重要。几十年来,临床前研究中女性模型的代表性不足导致了两性在疾病理解、疾病和治疗方面的差异。性别偏见的存在已被认为是临床前研究解释受限和可重复性的一个促成因素。许多呼吁行动强调了将性别作为一个生物学变量纳入研究的重要性,这一观点正获得越来越多的支持。尽管在将更多女性模型纳入临床前研究方面取得了重大进展,但差异仍然存在。本综述重点关注性别在生物医学研究中的作用及其普遍性,以及它们在药理学中的潜在作用,并分析潜在风险指南。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eead/11295939/09591f22b296/gr1.jpg

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