Intramural Research Program, National Institute on Aging, National Institutes of Health, 3001 S. Hanover Street, 5th Floor, Room NM536, Baltimore, MD 21225, USA.
Intramural Research Program, National Institute on Aging, National Institutes of Health, 3001 S. Hanover Street, 5th Floor, Room NM547, Baltimore, MD 21225, USA.
Endocrinol Metab Clin North Am. 2023 Jun;52(2):295-315. doi: 10.1016/j.ecl.2022.10.002. Epub 2023 Feb 16.
Taste is one of our five primary senses, and taste impairment has been shown to increase with aging. The ability to taste allows us to enjoy the food we eat and to avoid foods that are potentially spoiled or poisonous. Recent advances in our understanding of the molecular mechanisms of taste receptor cells located within taste buds help us decipher how taste works. The discoveries of "classic" endocrine hormones in taste receptor cells point toward taste buds being actual endocrine organs. A better understanding of how taste works may help in reversing taste impairment associated with aging.
味觉是我们的五种主要感觉之一,味觉障碍随着年龄的增长而增加。味觉使我们能够享受我们所吃的食物,并避免食用可能变质或有毒的食物。我们对位于味蕾内的味觉受体细胞的分子机制的理解的最新进展帮助我们破译味觉是如何起作用的。在味觉受体细胞中发现“经典”内分泌激素的发现表明,味蕾实际上是内分泌器官。更好地了解味觉如何工作可能有助于逆转与年龄相关的味觉障碍。