Xu P, Yu J J, Zhang W Y, Yang D D, Sun C W, Chen X Y, Yuan Q, Ye S D, Zhao L, Liu Z F, Li J
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan 250014, China.
National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
Zhonghua Gan Zang Bing Za Zhi. 2023 Jan 20;31(1):49-55. doi: 10.3760/cma.j.cn501113-20221108-00551.
To understand the basic characteristics of previously reported patients with hepatitis C and analyze the related factors affecting their antiviral treatment. A convenient sampling method was adopted. Patients who had been previously diagnosed with hepatitis C in the Wenshan Prefecture of Yunnan Province and Xuzhou City of Jiangsu Province were contacted by telephone for an interview study. The Andersen health service utilization behavior model and related literature were used to design the research framework for antiviral treatment in previously reported hepatitis C patients. A step-by-step multivariate regression analysis was used in previously reported hepatitis C patients treated with antiviral therapy. A total of 483 hepatitis C patients, aged 51.73 ± 12.06 years, were investigated. The proportion of male, agricultural occupants who were registered permanent residents, farmers and migrant workers was 65.24%, 67.49%, and 58.18%, respectively. Han ethnicity (70.81%), married (77.02%), and junior high school and below educational level (82.61%) were the main ones. Multivariate logistic regression analysis results showed that married patients with hepatitis C ( = 3.19, 95% : 1.93-5.25, compared with unmarried, divorced, and widowed patients) with high school education or above ( = 2.54, 95% : 1.54-4.20, compared with patients with junior high school education or below) were more likely to receive antiviral treatment in the predisposition module. Patients with severe self-perceived hepatitis C in the need factor module (compared with patients with mild self-perceived disease, = 3.36, 95% : 2.09-5.40) were more likely to receive treatment. In the competency module, the family's per capita monthly income was more than 1,000 yuan (compared with patients with per capita monthly income below 1,000 yuan, = 1.59, 95% : 1.02-2.47), and the patients had a high level of awareness of hepatitis C knowledge (compared with patients with a low level of knowledge, = 1.54, 95% : 1.01-2.35), and the family members who knew the patient's infection status (compared with patients with an unknown infection status, = 4.59, 95% : 2.24-9.39) were more likely to receive antiviral treatment. Different income, educational, and marital statuses are related to antiviral treatment behavior in hepatitis C patients. Family support of hepatitis C patients receiving hepatitis C-related knowledge and their families knowing the infection status is more important in promoting the antiviral treatment of patients, suggesting that in the future, we should further strengthen the hepatitis C knowledge of hepatitis C patients, especially the family support of hepatitis C patients' families in treatment.
了解既往报告的丙型肝炎患者的基本特征,并分析影响其抗病毒治疗的相关因素。采用方便抽样法。通过电话联系云南省文山州和江苏省徐州市既往诊断为丙型肝炎的患者进行访谈研究。运用安德森健康服务利用行为模型及相关文献设计既往报告的丙型肝炎患者抗病毒治疗的研究框架。对接受抗病毒治疗的既往报告的丙型肝炎患者进行逐步多因素回归分析。共调查了483例丙型肝炎患者,年龄为51.73±12.06岁。男性、农业户籍常住人口、农民和农民工的比例分别为65.24%、67.49%和58.18%。汉族(70.81%)、已婚(77.02%)以及初中及以下文化程度(82.61%)者居多。多因素logistic回归分析结果显示,在倾向模块中,已婚丙型肝炎患者(比值比=3.19,95%可信区间:1.93 - 5.25,与未婚、离异和丧偶患者相比)以及高中及以上文化程度患者(比值比=2.54,95%可信区间:1.54 - 4.20,与初中及以下文化程度患者相比)更有可能接受抗病毒治疗。在需求因素模块中,自我感觉丙型肝炎病情严重的患者(与自我感觉病情较轻的患者相比,比值比=3.36,95%可信区间:2.09 - 5.40)更有可能接受治疗。在能力模块中,家庭人均月收入超过1000元(与家庭人均月收入低于1000元的患者相比,比值比=1.59,95%可信区间:1.02 - 2.47)、患者对丙型肝炎知识知晓程度高(与知识水平低的患者相比,比值比=1.54,95%可信区间:1.01 - 2.35)以及家庭成员知晓患者感染状况(与感染状况未知的患者相比,比值比=4.59,95%可信区间:2.24 - 9.39)的患者更有可能接受抗病毒治疗。不同的收入、教育和婚姻状况与丙型肝炎患者的抗病毒治疗行为有关。丙型肝炎患者获得丙型肝炎相关知识的家庭支持以及其家庭成员知晓感染状况在促进患者抗病毒治疗方面更为重要,提示未来应进一步加强丙型肝炎患者的丙型肝炎知识,尤其是丙型肝炎患者家庭在治疗方面的支持。