Hsieh S D, Yamamoto R, Saito K, Iwamoto Y, Kuzuya T, Ohba S, Kobori S, Saito K
Division of Endocrinology and Metabolism, Jichi Medical School, Tochigi-ken, Japan.
Jpn J Med. 1987 Aug;26(3):393-5. doi: 10.2169/internalmedicine1962.26.393.
A 67-year-old male patient presented with rapid progression of whitening and loss of hair in past 2 months was consulted due to the suspicion of hypothyroidism. He had been told to have cardiomegaly for 3 years. Thyroid function was within normal limit. Prostate biopsy was performed because of prostatic hypertrophy and mild elevation of serum acid phosphatase. Amyloid accumulation was observed in the biopsy specimen. Subsequent skin biopsies revealed the same result. The scalp hair and beard grew and turned to black gradually several months after dimethyl sulfoxide (DMSO) treatment. These findings suggest that some of the manifestation of amyloidosis may respond to DMSO treatment.
一名67岁男性患者，因怀疑甲状腺功能减退前来咨询，其在过去2个月内出现头发迅速变白和脱落。他被告知患有心脏肥大已有3年。甲状腺功能正常。因前列腺肥大和血清酸性磷酸酶轻度升高进行了前列腺活检。在活检标本中观察到淀粉样蛋白沉积。随后的皮肤活检也得到了相同结果。在二甲基亚砜（DMSO）治疗数月后，头皮毛发和胡须逐渐生长并变黑。这些发现表明，淀粉样变性的一些表现可能对DMSO治疗有反应。
