Shibuya T, Murakawa M, Tsuda Y, Harada M
First Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Intern Med. 1992 Apr;31(4):544-8. doi: 10.2169/internalmedicine.31.544.
A 42-year-old Japanese male was admitted to our hospital because of congestive heart failure (CHF). A diagnosis of primary amyloidosis was made on the basis of a heavy deposition of amyloid in the gastric submucosal tissue in addition to the hematological and immunological findings. Intermittent chemotherapy in combination with daily oral dimethylsulfoxide (DMSO) resulted in a dramatic decrease of plasma cells in the marrow as well as a gradual improvement of CHF. With this therapy, the cardiac ejection fraction was markedly improved. This case indicates that the long-standing administration of DMSO combined with cytoreductive chemotherapy is therefore effective in treating some cases with primary amyloidosis.
一名42岁的日本男性因充血性心力衰竭（CHF）入住我院。除血液学和免疫学检查结果外，根据胃黏膜下组织中淀粉样蛋白的大量沉积，诊断为原发性淀粉样变性。间歇性化疗联合每日口服二甲基亚砜（DMSO）导致骨髓中浆细胞显著减少，同时CHF逐渐改善。通过这种治疗，心脏射血分数明显提高。该病例表明，长期给予DMSO联合细胞减灭化疗对治疗某些原发性淀粉样变性病例有效。
