长期服用阿仑膦酸钠导致 36 岁女性发生非典型股骨干骨折：病例报告及文献复习。
Long-term administration of alendronate sodium caused an atypical femoral shaft fracture in a 36-year-old woman: a case report and literature review.
机构信息
BaoTou Medical College, Inner Mongolia University of Science and Technology, BaoTou, China.
Orthopaedic Trauma Ward 1, The First Affiliated Hospital of BaoTou Medical College, Inner Mongolia University of Science and Technology, BaoTou, China.
出版信息
J Int Med Res. 2024 Oct;52(10):3000605241286650. doi: 10.1177/03000605241286650.
Long-term bisphosphonate therapy is associated with atypical or insufficiency fractures, particularly in the proximal femur. We observed a case of an atypical femoral shaft fracture in a patient with a long-term history of alendronate therapy. A 36-year-old woman was admitted with a complaint of pain in her right mid-thigh following low-energy trauma. She had been taking alendronate for more than 15 years. X-rays indicated a fracture of the right femoral shaft. The patient was treated with proximal femoral nail antirotation (PFNA) fixation. This case highlights concerns regarding long-term bisphosphonate therapy and its potential complications.
长期使用双膦酸盐治疗与非典型或不充分性骨折有关，尤其是在股骨近端。我们观察到一例长期使用阿仑膦酸钠治疗的患者发生非典型股骨干骨折。一名 36 岁女性因低能量创伤后出现右大腿中段疼痛而入院。她已服用阿仑膦酸钠超过 15 年。X 光片显示右侧股骨干骨折。患者接受了股骨近端防旋髓内钉（PFNA）固定治疗。该病例强调了对长期双膦酸盐治疗及其潜在并发症的关注。
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