Deng Li-Hong, Wei Wei, Qiao Chun-Xia, Yin Yu-Bing, Jian Ling-Qi, Li Tao
Mental Health Center and Psychiatric Laboratory, the State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Affiliated Mental Health Center, Zhejiang University School of Medicine & Hangzhou Seventh People's Hospital, Hangzhou 310013, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Mar;54(2):281-286. doi: 10.12182/20230360103.
To investigate frequency-specific alterations of spontaneous brain activity in first-episode drug-naïve schizophrenia (SZ) patients and the associations with clinical symptoms.
We collected the resting-state functional MRI (rs-fMRI) data from 84 first-episode drug-naïve SZ patients and 94 healthy controls (HCs) and calculated the amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo) of four frequency bands, including slow-2, slow-3, slow-4, and slow-5. Two-sample -tests were used to evaluate the intergroup differences in ALFF and ReHo, while partial correlation analyses were conducted to explore the associations between abnormal ALFF and ReHo and the severity of clinical symptoms in the SZ group.
Compared with HCs, the SZ group showed reduced ALFF in superior cerebellum and cerebellar vermis across slow-2, slow-3, and slow-4 bands, while increased ALFF was found in left superior temporal gyrus, middle temporal gyrus, and superior temporal pole at slow-4 band. Moreover, reduced ReHo was observed in the right precentral and postcentral gyri at slow-3 band in the SZ group. Additionally, the ALFF of left superior temporal gyrus, middle temporal gyrus, and superior temporal pole in slow-4 band showed a trend of positive correlation with the excited factor score of Positive and Negative Syndrome Scale (PANSS) in the SZ group.
Our results suggest that local alterations of spontaneous brain activity were frequency-specific in first-episode drug-naïve SZ patients.
探讨首发未服药的精神分裂症（SZ）患者脑自发活动的频率特异性改变及其与临床症状的相关性。
我们收集了84例首发未服药的SZ患者和94例健康对照（HCs）的静息态功能磁共振成像（rs-fMRI）数据，并计算了四个频段（包括慢波2、慢波3、慢波4和慢波5）的低频振幅（ALFF）和局部一致性（ReHo）。采用双样本t检验评估ALFF和ReHo的组间差异，同时进行偏相关分析以探讨SZ组中异常ALFF和ReHo与临床症状严重程度之间的相关性。
与HCs相比，SZ组在慢波2、慢波3和慢波4频段的小脑上蚓部和小脑蚓部的ALFF降低，而在慢波4频段左侧颞上回、颞中回和颞极的ALFF升高。此外，SZ组在慢波3频段右侧中央前回和中央后回的ReHo降低。此外，SZ组慢波4频段左侧颞上回、颞中回和颞极的ALFF与阳性和阴性症状量表（PANSS）的兴奋因子评分呈正相关趋势。
我们的结果表明，首发未服药的SZ患者脑自发活动的局部改变具有频率特异性。
