Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China; The Aga Khan University of East Africa, PO Box 125, Dar es Salaam, Tanzania.
Mental Health Institute of the Second Xiangya Hospital, Key Laboratory of Psychiatry and Mental Health of Hunan Province, Central South University, Changsha, Hunan 410011, China.
Schizophr Res. 2017 Nov;189:9-18. doi: 10.1016/j.schres.2017.02.026. Epub 2017 Mar 3.
In the last two decades there has been an increase on task and resting-state functional Magnetic Resonance Imaging (fMRI) studies that explore the brain's functional changes in schizophrenia. However, it remains unclear as to whether the brain's functional changes during the resting state are sensitive to the same brain regions during task fMRI. Therefore, we conducted a systematic literature search of task and resting-state fMRI studies that investigated brain pathological changes in first-episode schizophrenia (Fleischhacker et al.). Nineteen studies met the inclusion criteria; seven were resting state fMRI studies with 371 FES patients and 363 healthy controls and twelve were task fMRI studies with 235 FES patients and 291 healthy controls. We found overlapping task and resting-state fMRI abnormalities in the prefrontal regions, including the dorsal lateral prefrontal cortex, the orbital frontal cortex and the temporal lobe, especially in the left superior temporal gyrus (STG). The findings of this systematic review support the frontotemporal hypothesis of schizophrenia, and the disruption in prefrontal and STG might represent the pathophysiology of schizophrenia disorder at a relatively early stage.
在过去的二十年中，越来越多的任务和静息态功能磁共振成像（fMRI）研究探索了精神分裂症患者大脑的功能变化。然而，目前尚不清楚静息态下大脑的功能变化是否对任务 fMRI 期间的相同脑区敏感。因此，我们对首次发作精神分裂症（Fleischhacker 等人）的任务和静息态 fMRI 研究进行了系统的文献检索。符合纳入标准的研究有 19 项；其中 7 项是静息态 fMRI 研究，纳入 371 名首发精神分裂症患者和 363 名健康对照者，12 项是任务 fMRI 研究，纳入 235 名首发精神分裂症患者和 291 名健康对照者。我们发现前额叶区域的任务和静息态 fMRI 异常存在重叠，包括背外侧前额叶皮质、眶额皮质和颞叶，尤其是左侧颞上回（STG）。这一系统综述的研究结果支持精神分裂症的额颞叶假说，前额叶和 STG 的紊乱可能代表精神分裂症障碍在相对较早阶段的病理生理学改变。
