Xu Jian, Wang Wen-Zhi, Fan Xue, Wang Lu, Zhang Meng
Department of Osteoporosis and Rheumatology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China.
Sichuan Da Xue Xue Bao Yi Xue Ban. 2023 Mar;54(2):439-443. doi: 10.12182/20230360504.
To investigate the influence of osteoarthritis (OA) at different sites and of different degrees on the prevalence of osteoporosis (OP) and lumbar bone mineral density (L-BMD) in men, and thereby to analyze the relationship between OA and OP.
We collected information on the age, height, body mass, the course of pain, smoking status, exercise status, and history of hypertension and diabetes of 1206 male patients who received treatment for bone and joint pain at the Department of Osteoporosis and Rheumatology, West China Fourth Hospital, Sichuan University between January 2017 and December 2020. The patients' L-BMD was determined with dual-energy X-ray absorptiometry. The sites and the degrees of OA were evaluated by digital radiography and CT or MRI. test was performed to compare the OP prevalence of different groups. Analysis of covariance was carried out to compare the L-BMD of different groups. Binary logistic regression was conducted to analyze the risk factors of OP.
OP prevalence of the OA group was significantly lower than that of the non-OA group ( <0.05). OP prevalence of the lumbar vertebra OA group was significantly lower than that of the non-OA group ( <0.05). In addition, OP prevalence of the mild OA group and moderate OA group was significantly lower than of the non-OA group ( <0.05). The L-BMD of the OA group was significantly higher than that of the non-OA group ( <0.05). In addition, there were significant differences in L-BMD between groups with OA at different sites ( <0.05). Furthermore, the L-BMD of the lumbar vertebra OA group and the multi-site OA group was significantly higher than that of the non-OA group ( <0.05). There were significant differences in L-BMD between groups with different degrees of OA ( <0.05). Furthermore, the L-BMD of the mild OA group and moderate OA group was significantly higher than that of the non-OA group ( <0.05). OA and exercise were found to be protective factors for OP (odds ratio [ ]=0.715 and 0.625, 95% confidence interval [ ]: 0.550-0.928 and 0.481-0.814, <0.05). Age and BMI were found to be risk factors for OP in men ( =1.018 and 1.081, 95% : 1.008-1.028 and 1.042-1.122, <0.05).
Lumbar vertebra OA and mild and moderate OA decrease OP prevalence in men, while lumbar vertebra OA, multi-site OA, and mild and moderate OA increase L-BMD in men. OA and exercise decrease the occurrence of OP in men, while age and BMI increase the risk of OP in men.
探讨不同部位、不同程度的骨关节炎（OA）对男性骨质疏松症（OP）患病率及腰椎骨密度（L-BMD）的影响，进而分析OA与OP之间的关系。
收集2017年1月至2020年12月在四川大学华西第四医院骨质疏松与风湿免疫科接受骨关节疼痛治疗的1206例男性患者的年龄、身高、体重、疼痛病程、吸烟状况、运动状况以及高血压和糖尿病病史等信息。采用双能X线吸收法测定患者的L-BMD。通过数字X线摄影和CT或MRI评估OA的部位和程度。采用 检验比较不同组的OP患病率。进行协方差分析比较不同组的L-BMD。采用二元逻辑回归分析OP的危险因素。
OA组的OP患病率显著低于非OA组（<0.05）。腰椎OA组的OP患病率显著低于非OA组（<0.05）。此外，轻度OA组和中度OA组的OP患病率显著低于非OA组（<0.05）。OA组的L-BMD显著高于非OA组（<0.05）。此外，不同部位OA组之间的L-BMD存在显著差异（<0.05）。此外，腰椎OA组和多部位OA组的L-BMD显著高于非OA组（<0.05）。不同程度OA组之间的L-BMD存在显著差异（<0.05）。此外，轻度OA组和中度OA组的L-BMD显著高于非OA组（<0.05）。发现OA和运动是OP的保护因素（比值比[ ]=0.715和0.625，95%置信区间[ ]：0.550-0.928和0.481-0.814，<0.05）。发现年龄和BMI是男性OP 的危险因素（ =1.018和1.081，95% ：1.008-1.028和1.042-1.122，<0.05）。
腰椎OA以及轻度和中度OA可降低男性OP患病率，而腰椎OA、多部位OA以及轻度和中度OA可增加男性L-BMD。OA和运动可降低男性OP的发生，而年龄和BMI会增加男性OP的风险。
