Bhattacharya Haimanti, Parai Debaprasad, Sahoo Subrat Kumar, Swain Aparjita, Pattnaik Matrujyoti, Mohapatra Ira, Choudhary Hariram, Dash Girish Chandra, Akhtar Nausaba, Kshatri Jaya Singh, Bhattacharya Debdutta, Pati Sanghamitra
Department of Microbiology, ICMR - Regional Medical Research Centre, Bhubaneswar, Odisha, India.
Front Microbiol. 2023 Mar 6;14:1039696. doi: 10.3389/fmicb.2023.1039696. eCollection 2023.
The Global Health Sector Strategy on viral hepatitis (2016-2021) endorsed by the World Health Assembly in 2016, called for the elimination of viral hepatitis as a public health threat by 2030. Odisha, an eastern state of India, has the third-highest percentage of tribal population in the country and limited information is available regarding the prevalence of HBsAg among them. The present study was undertaken to estimate the seroprevalence of hepatitis B surface antigen as well as HBV DNA almost after 12 years of the first prevalence study of HBsAg among the tribal community of Odisha. The present study attempted to estimate the prevalence of HBsAg among the 35 Scheduled tribal (ST) communities and 5 Particularly Vulnerable Tribal Group (PVTG) using the 2,737 number of sera collected as part of a statewide COVID-19 serosurvey, among the tribal populations of Odisha (residing in 7 districts) aged 6-75 years. HBsAg positivity ranged between 1.79 and 2.94% across various age groups. 42.9% of HBsAg positive individuals showed the presence of HBV DNA and the high viral load was 0.10 × 10-6.84 × 10 IU/mL, indicating a high potential to transmit the virus. The HBsAg positivity was 14.18 and 6.06% among the PVTGs, Kutia Khond and Paudi Bhuyan, who were first time surveyed for HBsAg prevalence. The present study documents the prevalence of HBsAg among the major tribal population residing in the eastern state of the country and highlights the need for a statewide survey of Hepatitis B infection and risk factors, coverage and impact of the Hepatitis B vaccination program introduced in 2010-2011 in Odisha among the ST and PVTG population of the state.
2016年世界卫生大会批准的《全球卫生部门病毒性肝炎战略（2016 - 2021年）》呼吁到2030年消除病毒性肝炎这一公共卫生威胁。印度东部的奥里萨邦，其部落人口占比在全国位列第三，然而关于该邦部落人群中乙肝表面抗原（HBsAg）流行情况的信息却十分有限。本研究开展的目的是，在奥里萨邦部落社区首次进行HBsAg流行率研究近12年后，估算乙肝表面抗原以及乙肝病毒脱氧核糖核酸（HBV DNA）的血清流行率。本研究试图利用作为全州范围新冠病毒血清学调查一部分所收集的2737份血清样本，估算奥里萨邦（居住在7个区）6至75岁部落人群中35个在册部落（ST）社区和5个特别脆弱部落群体（PVTG）的HBsAg流行率。各年龄组的HBsAg阳性率在1.79%至2.94%之间。42.9%的HBsAg阳性个体检测出HBV DNA存在，高病毒载量为0.10×10 - 6.84×10国际单位/毫升，这表明该病毒具有较高的传播潜力。在首次接受HBsAg流行率调查的PVTG群体库提亚孔德和包迪布扬中，HBsAg阳性率分别为14.18%和6.06%。本研究记录了该国东部邦主要部落人群中HBsAg的流行情况，并强调有必要在全州范围内对乙肝感染及风险因素、2010 - 2011年在奥里萨邦推行的乙肝疫苗接种计划在该邦ST和PVTG人群中的覆盖情况及影响进行调查。
