用于光动力疗法的多层光学血管造影术。
Multi-level optical angiography for photodynamic therapy.
作者信息
Du Qianyi, Yi Min, Li Hongyi, Liu Jiayi, Guan Caizhong, Zeng Yaguang, Xiong Honglian, Wang Xuehua, Zhong Junping, Wu Yanxiong, Tan Haishu, Han Dingan, Wang Mingyi
机构信息
Guangdong-Hong Kong-Macao Joint Laboratory for Intelligent Micro-Nano Optoelectronic Technology, School of Physics and Optoelectronic Engineering, Foshan University, Foshan 528225, China.
Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, Foshan University, Foshan 528225, China.
出版信息
Biomed Opt Express. 2023 Feb 9;14(3):1082-1095. doi: 10.1364/BOE.473644. eCollection 2023 Mar 1.
Blood flow imaging is widely applied in photodynamic therapy (PDT) to provide vascular morphological and statistical parameters. This approach relies on the intensity of time-domain signal differences between blood vessels and background tissues; therefore, it often ignores differences within the vasculature and cannot accommodate abundant structural information. This study proposes a multi-level optical angiography (MOA) method for PDT. It can enhance capillaries and image vessels at different levels by measuring the signal frequency shift associated with red blood cell motion. The experimental results regarding the PDT-induced chorioallantoic membrane model showed that the proposed method could not only perform multi-level angiography but also provide more accurate quantitative information regarding various vascular parameters. This MOA method has potential applications in PDT studies.
血流成像在光动力疗法（PDT）中被广泛应用，以提供血管形态和统计参数。这种方法依赖于血管与背景组织之间时域信号差异的强度；因此，它常常忽略脉管系统内部的差异，并且无法容纳丰富的结构信息。本研究提出了一种用于光动力疗法的多级光学血管造影（MOA）方法。它可以通过测量与红细胞运动相关的信号频移来增强毛细血管并对不同层次的血管进行成像。关于光动力疗法诱导的鸡胚绒毛尿囊膜模型的实验结果表明，所提出的方法不仅可以进行多级血管造影，还能提供有关各种血管参数的更准确的定量信息。这种多级光学血管造影方法在光动力疗法研究中具有潜在的应用价值。
Zotero 插件