Absolute Grüneisen parameter measurement in deep tissue based on X-ray-induced acoustic computed tomography.

The Grüneisen parameter is a primary parameter of the initial sound pressure signal in the photoacoustic effect, which can provide unique biological information and is related to the temperature change information of an object. The accurate measurement of this parameter is of great significance in biomedical research. Combining X-ray-induced acoustic tomography and conventional X-ray computed tomography, we proposed a method to obtain the absolute Grüneisen parameter. The theory development, numerical simulation, and biomedical application scenarios are discussed. The results reveal that our method not only can determine the Grüneisen parameter but can also obtain the body internal temperature distribution, presenting its potential in the diagnosis of a broad range of diseases.