Ning Qiuping, Fan Tiebing, Ren Hua, Ye Huiyi, Wang Wensheng
Qiuping Ning, Medical School of Chinese PLA, Beijing, 100853, China; Department of Radiology, The First Medical Centre, Chinese PLA General Hospital, Beijing, 100853, China, Department of Radiology, China Academy of Chinese Medical Sciences Xiyuan Hospital, Beijing, 100091, China.
Tiebing Fan, Postdoctoral Management Office, Chinese Academy of Chinese Medical Sciences, Beijing, 100853, China.
Pak J Med Sci. 2023 Mar-Apr;39(2):417-422. doi: 10.12669/pjms.39.2.6094.
To evaluate lesions of sacroiliac joint (SIJ) by combination of diffusion-weighted imaging (DWI) and magnetization transfer (MT).
A retrospective study was used in this study. Forty-nine ankylosing spondylitis (AS) patients admitted to The China Academy of Chinese Medical Sciences Xiyuan Hospital from May 2020 to October 2020 were collected into active and inactive groups. Twenty-two healthy volunteers were recruited. Apparent diffusion coefficient (ADC) values for bone marrow edema (BME), sclerosis area, fat deposit area, and normal-appearing bone marrow (NABM) (both patients and healthy volunteers) and the magnetization transfer (MT) rate of the cartilage (MTRc) were analyzed in the groups. The above five parameters (ADC (NABM), ADC (BME) and ADC (fat deposit) and MTRc) between the active group and the inactive group were compared. The effectiveness of each parameter in diagnosing sacroiliac arthritis of ankylosing spondylitis were analyzed, and the predictive value of the parameters was compared.
ADC(BME), ADC(NABM) and MTRc showed statistically significant differences between the active and inactive groups ( <0.05). ADC (BME) and ADC (NABM) could predict the activity of AS sacroiliac arthritis ( <0.01). ADC (NABM) and MTRc were significantly different between healthy volunteers and the active group ( <0.01). The areas under the ROC curve (AUCs) of ADC (BME)_ADC(NABM), ADC(NABM)_MTR, and ADC(BME)_MTRc were 0.885 (cut-off value=0.69), 0.849 (cut-off value=0.56) and 0.864 (cut-off value=0.60), respectively. The predictive ability of the combined index ADC (BME)_MTRc and ADC(NABM)_MTRc was increased.
The ability to diagnose and predict AS might be improved by the combination of diffusion-weighted imaging (DWI) and magnetization transfer (MT).
通过扩散加权成像（DWI）与磁化传递（MT）相结合的方法评估骶髂关节（SIJ）病变。
本研究采用回顾性研究。收集2020年5月至2020年10月在中国中医科学院西苑医院收治的49例强直性脊柱炎（AS）患者，分为活动组和非活动组。招募22名健康志愿者。分析两组患者及健康志愿者骨髓水肿（BME）、硬化区、脂肪沉积区和正常骨髓（NABM）的表观扩散系数（ADC）值以及软骨的磁化传递（MT）率（MTRc）。比较活动组与非活动组上述五个参数（ADC（NABM）、ADC（BME）、ADC（脂肪沉积）和MTRc）。分析各参数对强直性脊柱炎骶髂关节炎的诊断效能，并比较各参数的预测价值。
活动组与非活动组之间ADC（BME）、ADC（NABM）和MTRc差异有统计学意义（<0.05）。ADC（BME）和ADC（NABM）可预测AS骶髂关节炎的活动度（<0.01）。健康志愿者与活动组之间ADC（NABM）和MTRc差异有统计学意义（<0.01）。ADC（BME）_ADC（NABM）、ADC（NABM）_MTR和ADC（BME）_MTRc的ROC曲线下面积（AUC）分别为0.885（截断值=0.69）、0.849（截断值=0.56）和0.864（截断值=0.60）。联合指标ADC（BME）_MTRc和ADC（NABM）_MTRc的预测能力增强。
扩散加权成像（DWI）与磁化传递（MT）相结合可能提高强直性脊柱炎的诊断和预测能力。
