Zhu Kaiquan, Lin Renyu
Kaiquan Zhu, Department of Otorhinolaryngology,The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000 P.R. China.
Renyu Lin, Department of Otorhinolaryngology,The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang Province, 325000 P.R. China.
Pak J Med Sci. 2023 Mar-Apr;39(2):349-353. doi: 10.12669/pjms.39.2.6847.
To compare the therapeutic effects of low-temperature plasma radiofrequency ablation and partial laryngectomy in the treatment of early glottis carcinoma.
Clinical data of 80 patients with early glottis carcinoma treated in our hospital from June 2019 to January 2021 were analyzed. Patients were retrospectively divided into two groups based on the type of intervention. Forty patients received partial laryngectomy (Control group) and 40 patients received low-temperature plasma radiofrequency ablation (Observation group). Surgical indexes, length of hospital stay, postoperative complications, and visual analog scale (VAS) score of postoperative pain of patients in the two groups were compared. Postoperative stress response indexes, clinical efficacy, and postoperative recovery in two groups were compared and analyzed.
The operation time, hospital stay, intraoperative bleeding, and the incidence of postoperative complications in the observation group were significantly lower than those in the Control group (<0.05). The postoperative pain VAS scores, Levels of malondialdehyde (MDA) and glutathione (GSH) in the observation group were significantly lower than those in the control group (<0.05), while the level of nitro tyrosine (3-NT) and superoxide dismutase (SOD) were significantly higher than that in the control group (<0.05). After a one-year follow-up, the excellent and good rate of pronunciation function in the observation group (95%) was significantly higher than control group (75%) (<0.05).
Low-temperature plasma radiofrequency ablation in the treatment of early glottis carcinoma is associated with less trauma, short operation time, less bleeding, short hospital stay and low postoperative stress reaction rate. Compared with partial laryngectomy, it has higher safety and better postoperative vocal cord function recovery.
比较低温等离子射频消融术与部分喉切除术治疗早期声门癌的疗效。
分析2019年6月至2021年1月在我院治疗的80例早期声门癌患者的临床资料。根据干预类型将患者回顾性分为两组。40例患者接受部分喉切除术（对照组），40例患者接受低温等离子射频消融术（观察组）。比较两组患者的手术指标、住院时间、术后并发症及术后疼痛视觉模拟量表（VAS）评分。比较分析两组患者术后应激反应指标、临床疗效及术后恢复情况。
观察组的手术时间、住院时间、术中出血量及术后并发症发生率均显著低于对照组（<0.05）。观察组术后疼痛VAS评分、丙二醛（MDA）和谷胱甘肽（GSH）水平均显著低于对照组（<0.05），而硝基酪氨酸（3-NT）和超氧化物歧化酶（SOD）水平显著高于对照组（<0.05）。随访1年后，观察组发音功能优良率（95%）显著高于对照组（75%）（<0.05）。
低温等离子射频消融术治疗早期声门癌创伤小、手术时间短、出血少、住院时间短、术后应激反应率低。与部分喉切除术相比，其安全性更高，术后声带功能恢复更好。
