Ye Mingfu, Liu Wenjun, Cheng Shaolong, Yan Lihui
Mingfu Ye, Department of Oral Implantology, Stomatological Hospital of Xiamen Medical College, Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Xiamen 361008, Fujian Province, P.R. China.
Wenjun Liu, Department of Oral Implantology, Stomatological Hospital of Xiamen Medical College, Xiamen Key Laboratory of Stomatological Disease Diagnosis and Treatment, Xiamen 361008, Fujian Province, P.R. China.
Pak J Med Sci. 2023 Mar-Apr;39(2):595-604. doi: 10.12669/pjms.39.2.7253.
The current review aimed to assess the efficacy of adjunctive chlorhexidine (CHX) in the non-surgical treatment of peri-implantitis/peri-implant mucositis.
PubMed, Embase, Science Direct, CENTRAL, and Google Scholar databases were searched up to 10 March 2022 for relevant randomized controlled trials or controlled clinical trials.
Fourteen studies were included. Meta-analysis revealed significantly lower probing depths in peri-implant mucositis patients using CHX adjuncts as compared to controls (SMD: -1.49 95% CI: -2.56, -0.42 I2=95% p=0.006). However, the same effect was not noted in peri-implantitis (SMD: -1.18 95% CI: -0.04, 2.40 I2=96% p=0.06). CHX was not found to improve bleeding of probing in peri-implant mucositis while sufficient data was unavailable for peri-implantitis. Results on other outcome variables were conflicting.
Evidence on the efficacy of adjunctive CHX for peri-implant mucositis is conflicting. Similarly, strong conclusions on the effect of CHX for peri-implantitis cannot be drawn due to limited number of studies. Overall, there seems to be a trend of non-significant impact of CHX on outcomes of peri-implant mucositis as well as peri-implantitis.
本综述旨在评估洗必泰（CHX）辅助治疗种植体周围炎/种植体周围黏膜炎的非手术治疗效果。
检索截至2022年3月10日的PubMed、Embase、Science Direct、CENTRAL和谷歌学术数据库，查找相关随机对照试验或对照临床试验。
纳入14项研究。荟萃分析显示，与对照组相比，使用CHX辅助治疗的种植体周围黏膜炎患者的探诊深度显著降低（标准化均数差：-1.49，95%可信区间：-2.56，-0.42，I2 = 95%，p = 0.006）。然而，在种植体周围炎患者中未观察到相同效果（标准化均数差：-1.18，95%可信区间：-0.04，2.40，I2 = 96%，p = 0.06）。未发现CHX能改善种植体周围黏膜炎的探诊出血情况，而关于种植体周围炎的相关数据不足。其他结局变量的结果相互矛盾。
关于CHX辅助治疗种植体周围黏膜炎疗效的证据相互矛盾。同样，由于研究数量有限，无法就CHX对种植体周围炎的影响得出强有力的结论。总体而言，CHX对种植体周围黏膜炎和种植体周围炎结局的影响似乎有不显著的趋势。
