ETEP (Etiology and Therapy of Periodontal and Peri-implant Diseases) Research Group, Faculty of Dentistry, University Complutense of Madrid, Madrid, Spain.
Department of Dental Clinical Specialties, Faculty of Dentistry, Complutense University of Madrid, Plaza de Ramón y Cajal, s/n, 28040, Madrid, Spain.
Clin Oral Investig. 2021 Apr;25(4):1729-1741. doi: 10.1007/s00784-020-03474-3. Epub 2020 Jul 31.
To evaluate the efficacy of a 0.03% chlorhexidine (CHX) and 0.05% cetylpyridinium chloride (CPC) mouth rinse, as an adjunct to professional plaque removal (PPR) and mechanical hygiene, in the treatment of peri-implant mucositis (PiM) and gingivitis.
Patients displaying PiM in, at least, one implant were included in this randomized, double-blinded, clinical trial. Subjects received PPR (at baseline and 6-month visits) and were instructed to rinse, twice daily, during 1 year with the tested mouth rinse or a placebo. Clinical and patient-reported outcomes were recorded at baseline and 6 and 12 months.
Fifty-four patients were included in the study and 46 attended the final visit. In the teeth and implants with inflammation, a higher reduction in BOP was observed in the test group. Statistically significant differences between groups were only observed in the lingual sites of the teeth with gingivitis (mean difference = 11.96%; 95% confidence interval [1.09; 22.83]; p = 0.03). Overall, compliance and satisfaction were good, even though staining were higher for the test group (p < 0.05).
The combined use of mechanical debridement with a 0.03% CHX and 0.05% CPC mouth rinse may have adjunctive benefits in the management of gingivitis, and it is associated with a higher degree of staining.
The control of gingivitis can be improved, after professional mechanical debridement, with toothbrushing and the supplementary use of a 0.03% CHX and 0.05% CPC mouth rinse at home.
NCT03533166.
评估 0.03%洗必泰（CHX）和 0.05%十六烷基吡啶（CPC）漱口水作为专业牙菌斑去除（PPR）和机械清洁辅助治疗的疗效，用于治疗种植体周围黏膜炎（PiM）和牙龈炎。
本随机、双盲、临床试验纳入了至少一个种植体上存在 PiM 的患者。受试者接受 PPR（基线和 6 个月访视），并被指示在 1 年内每天使用两次测试漱口水或安慰剂进行漱口。在基线、6 个月和 12 个月记录临床和患者报告的结果。
本研究共纳入 54 名患者，其中 46 名患者完成了最终访视。在有炎症的牙齿和种植体中，实验组的 BOP 降低幅度更大。仅在牙龈炎牙齿的舌侧部位观察到组间存在统计学显著差异（平均差异=11.96%；95%置信区间[1.09；22.83]；p=0.03）。总体而言，即使实验组的染色更高（p<0.05），但依从性和满意度仍较好。
机械清创联合使用 0.03%CHX 和 0.05%CPC 漱口水可能对牙龈炎的治疗具有辅助作用，并且与更高程度的染色相关。
在专业机械清创后，通过刷牙和在家中补充使用 0.03%CHX 和 0.05%CPC 漱口水，可以改善牙龈炎的控制。
NCT03533166。
