Khan Nauman Rauf, Naseem Nadia, Riaz Nabeela, Anjum Rabia, Khalid Sobia, Iqbal Asifa, Chaudhry Saima
Dr. Nauman Rauf Khan, BDS, M.Phil. Ph.D Scholar Dept. of Oral Pathology Department, University of Health Sciences, Lahore, Pakistan.
Dr. Nadia Naseem, MBBS, Ph.D., Dept. of Morbid Anatomy & Histopathology, University of Health Sciences, Lahore, Pakistan.
Pak J Med Sci. 2023 Mar-Apr;39(2):395-400. doi: 10.12669/pjms.39.2.7266.
To investigate the association between clinicopathological findings and tumor stage according to AJCC 2018 guidelines in patients suffering from Oral squamous cell carcinoma (OSCC).
A descriptive study was conducted from January 2019 to January 2020 at King Edward Medical University and University of Health Sciences on a total of 49 patients enrolled after obtaining written informed consent. Clinical and radiographic findings were recorded. Pathological reporting was done using AJCC 2018 cancer staging guidelines. Association between clinicopathological features with tumor stage and grade was assessed using Chi-square and Kruskal-Wallis test.
Mean age of the patients was 46.1 ± 10.6 years. Most of the tumors were of well differentiated type (49%) and moderately differentiated (40.8%) with predominant clinical stage III in 42.9% & IV in 44.9 % and primary tumor stage pT2 28.6% & pT3 36.7%. Significant difference was seen for primary tumor stage in relation to age, gender, depth of invasion, primary site, and size of tumor (p < 0.01). For clinical stages, significant difference was observed in the age, gender, size of tumor, nodal metastasis, and anatomical tumor site (p < 0.01).
Application of 8th Edition AJCC guidelines identifies the importance of the latest classification with strong association of latest stage criteria with age, gender, site of primary tumor, tumor thickness, depth of invasion, nodal metastasis and size of largest lymph node involved, and Level of Lymph node involved (level III & V) in a subset of patients from a developing country.
根据美国癌症联合委员会（AJCC）2018年指南，研究口腔鳞状细胞癌（OSCC）患者的临床病理特征与肿瘤分期之间的关联。
2019年1月至2020年1月在爱德华国王医科大学和健康科学大学进行了一项描述性研究，共纳入49例获得书面知情同意的患者。记录临床和影像学检查结果。使用AJCC 2018年癌症分期指南进行病理报告。采用卡方检验和克鲁斯卡尔-沃利斯检验评估临床病理特征与肿瘤分期及分级之间的关联。
患者的平均年龄为46.1±10.6岁。大多数肿瘤为高分化型（49%）和中分化型（40.8%），主要临床分期为III期的占42.9%，IV期的占44.9%，原发肿瘤分期pT2的占28.6%，pT3的占36.7%。在年龄、性别、浸润深度、原发部位和肿瘤大小方面，原发肿瘤分期存在显著差异（p<0.01）。对于临床分期，在年龄、性别、肿瘤大小、淋巴结转移和肿瘤解剖部位方面观察到显著差异（p<0.01）。
应用第8版AJCC指南确定了最新分类的重要性，在一个发展中国家的部分患者中，最新分期标准与年龄、性别、原发肿瘤部位、肿瘤厚度、浸润深度、淋巴结转移以及受累最大淋巴结的大小和淋巴结受累水平（III级和V级）密切相关。
