Mundhra Sandeep, Mohta Srikant, Gamanagatti Shivanand, Sharma Sanchit, Hemachandran Naren, Saraya Anoop
Department of Gastroenterology and Human Nutrition Unit, All India Institute of Medical Sciences, New Delhi, 110029, India.
Department of Radiodiagnosis, All India Institute of Medical Sciences, New Delhi, 110029, India.
J Clin Exp Hepatol. 2023 Mar-Apr;13(2):372-376. doi: 10.1016/j.jceh.2022.09.008. Epub 2022 Oct 14.
A 34-year-old male visited our hospital with complaints of recurrent episodes of altered behavior since past 6 months along with difficulty in walking since past 3 months. He was diagnosed of chronic liver disease in the past. Examination revealed spasticity and brisk deep tendon reflexes in both the lower limbs. His blood investigations and spinal cord imaging was normal. Based on his clinical features, a possibility of portosystemic shunting leading to portosystemic encephalopathy (PSE) and shunt myelopathy was suspected. A computed tomography portography showed a recanalized paraumblical vein draining portal blood into external iliac veins. Patient underwent shunt occlusion (Figure- 2). One month after the procedure, while there was no recurrence of symptoms of PSE, those of myelopathy remained unchanged. Shunt myelopathy is a rare complication of spontaneous or iatrogenic portosystemic shunts. Unlike PSE, the management of shunt myelopathy is uncertain due to limited evidence. Limited evidence suggests reversal of myelopathy after early shunt occlusion, highlighting the irreversible changes that may set in spinal cord due to delayed diagnosis. Our case highlights an important but a rare complication of portosystemic shunting in chronic liver disease which should be kept in mind if these patients develop symptoms attributable to spinal cord disease.
一名34岁男性因自6个月前起反复出现行为改变以及自3个月前起行走困难前来我院就诊。他既往被诊断为慢性肝病。检查发现双下肢痉挛及深腱反射亢进。他的血液检查和脊髓成像均正常。基于其临床特征,怀疑存在导致门体分流性脑病(PSE)和分流性脊髓病的门体分流。计算机断层扫描门静脉造影显示一条再通的脐旁静脉将门静脉血引流至髂外静脉。患者接受了分流闭塞术(图2)。术后1个月,PSE症状未复发,但脊髓病症状无变化。分流性脊髓病是自发性或医源性门体分流的一种罕见并发症。与PSE不同,由于证据有限,分流性脊髓病的治疗尚不确定。有限的证据表明早期分流闭塞后脊髓病可逆转,这突出了因诊断延迟可能在脊髓中出现的不可逆变化。我们的病例突出了慢性肝病门体分流的一种重要但罕见的并发症,如果这些患者出现可归因于脊髓疾病的症状,应予以考虑。