Nasri Elham, Reith John David
Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, College of Medicine, Gainesville, FL, USA.
Department of Pathology, Cleveland Clinic, Cleveland, OH, USA.
J Pathol Transl Med. 2023 Mar;57(2):81-87. doi: 10.4132/jptm.2023.02.23. Epub 2023 Mar 14.
Aneurysmal bone cyst (ABC) is a benign locally destructive bone neoplasm composed of multi-loculated blood-filled cystic spaces. The most common sites of involvement are the meta-diaphysis of the long bones and posterior elements of the vertebrae. Secondary, ABC-like changes can complicate a variety of other benign and malignant primary bone neoplasms, including giant cell tumor, fibrous dysplasia, and osteosarcoma. About two-third of primary ABCs have a rearrangement of the USP6 gene, which is not present in the ABC-like changes that occur secondary to other primary bone tumors (i.e., secondary ABC). Primary ABC of bone carries a variable but generally high rate of local recurrence. This paper provides an overview of the pathophysiology, clinical presentation, radiographic and pathologic findings, treatment, and prognosis of ABC.
动脉瘤样骨囊肿（ABC）是一种良性的局部侵袭性骨肿瘤，由多个充满血液的囊性腔隙组成。最常受累的部位是长骨的干骺端和椎体的后部结构。其次，ABC样改变可使多种其他良性和恶性原发性骨肿瘤复杂化，包括骨巨细胞瘤、骨纤维异常增殖症和骨肉瘤。约三分之二的原发性ABC存在USP6基因重排，而在继发于其他原发性骨肿瘤的ABC样改变（即继发性ABC）中不存在这种重排。原发性骨ABC具有不同但通常较高的局部复发率。本文概述了ABC的病理生理学、临床表现、影像学和病理学表现、治疗及预后。
