School of Public Health, Qingdao University, Qingdao, China.
Key Laboratory of Maricultural Organism Disease Control, Ministry of Agriculture and Rural Affairs, Yellow Sea fisheries research institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, China.
Ecotoxicol Environ Saf. 2023 Apr 1;254:114702. doi: 10.1016/j.ecoenv.2023.114702. Epub 2023 Mar 2.
The influence of air pollution on human health has sparked widespread concerns across the world. Previously, we found that exposure to ambient fine particulate matter (PM2.5) in our "real-ambient exposure" system can result in reduced lung function. However, the mechanism of organ-specific toxicity is still not fully elucidated. The balance of the microbiome contributes to maintaining lung and gut health, but the changes in the microbiome under PM2.5 exposure are not fully understood. Recently, crosstalk between nuclear factor E2-related factor 2 (Nrf2) and the microbiome was reported. However, it is unclear whether Nrf2 affects the lung and gut microbiomes under PM2.5 exposure. In this study, wild-type (WT) and Nrf2 (KO) mice were exposed to filtered air (FA) and real ambient PM2.5 (PM) in the " real-ambient exposure" system to examine changes in the lung and gut microbiomes. Here, our data suggested microbiome dysbiosis in lung and gut of KO mice under PM2.5 exposure, and Nrf2 ameliorated the microbiome disorder. Our study demonstrated the detrimental impacts of PM2.5 on the lung and gut microbiome by inhaled exposure to air pollution and supported the protective role of Nrf2 in maintaining microbiome homeostasis under PM2.5 exposure.
空气污染对人类健康的影响引起了全世界的广泛关注。此前，我们发现，在我们的“真实环境暴露”系统中，暴露于环境细颗粒物（PM2.5）会导致肺功能下降。然而，器官特异性毒性的机制仍未完全阐明。微生物组的平衡有助于维持肺和肠道健康，但 PM2.5 暴露下微生物组的变化尚不完全清楚。最近，核因子 E2 相关因子 2（Nrf2）与微生物组之间的串扰被报道。然而，尚不清楚 Nrf2 是否会影响 PM2.5 暴露下的肺和肠道微生物组。在这项研究中，野生型（WT）和 Nrf2（KO）小鼠在“真实环境暴露”系统中分别暴露于过滤空气（FA）和真实环境 PM2.5（PM），以检测肺和肠道微生物组的变化。在这里，我们的数据表明，PM2.5 暴露下 KO 小鼠的肺和肠道微生物组出现了失调，而 Nrf2 改善了微生物组的紊乱。我们的研究通过吸入空气污染表明了 PM2.5 对肺和肠道微生物组的有害影响，并支持 Nrf2 在维持 PM2.5 暴露下微生物组内稳态方面的保护作用。
