Beumont P J, Abraham S F, Argall W J, Turtle J R
Aust N Z J Med. 1978 Oct;8(5):509-14. doi: 10.1111/j.1445-5994.1978.tb02589.x.
Nine female patients with anorexia nervosa were studied, three of them at different stages of weight gain. Basal plasma LH (luteinising hormone) was depressed in emaciated patients, but basal plasma FSH (follicle stimulating hormone) was normal. LH was significantly lower in patients who had been amenorrhoeic for less than 24 months than in those whose amenorrhoea was of longer duration. LH and FSH levels were stimulated by LHRH (luteinizing hormone releasing hormone), infused at a rate of 0.5 microgram/min for four hours. One patient, tested at 60% of standard weight, had no LH response. In all other patients below 70% of standard, the maximal LH response occurred within the first hour of infusion. In patients at higher weights, the LH response was biphasic, and the maximal level was reached during the last hour of the infusion. The FSH response, similarly, approached maximal during the first hour in patients below 70% of standard, but continued to rise throughout the infusion in patients at higher weights. Body weight expressed as a percentage of standard correlated significantly with both phases of the LH response, but not with the FSH response. Most previous authors have found an association between low body weight and depressed pituitary gonadotrophins in anorexia nervosa. The present findings further elucidate this relationship.
对9名神经性厌食症女性患者进行了研究，其中3名处于体重增加的不同阶段。消瘦患者的基础血浆促黄体生成素（LH）水平降低，但基础血浆促卵泡生成素（FSH）水平正常。闭经时间少于24个月的患者LH水平显著低于闭经时间较长的患者。以0.5微克/分钟的速率输注促黄体生成素释放激素（LHRH）4小时，可刺激LH和FSH水平。一名体重为标准体重60%的患者无LH反应。在所有其他低于标准体重70%的患者中，最大LH反应在输注的第一小时内出现。体重较高的患者，LH反应呈双相性，在输注的最后一小时达到最高水平。同样，标准体重低于70%的患者，FSH反应在第一小时接近最大值，但体重较高的患者在整个输注过程中持续上升。以标准体重百分比表示的体重与LH反应的两个阶段均显著相关，但与FSH反应无关。大多数先前的作者发现神经性厌食症患者体重过低与垂体促性腺激素水平降低之间存在关联。目前的研究结果进一步阐明了这种关系。
