Isaacs A J, Leslie R D, Gomez J, Bayliss R
Acta Endocrinol (Copenh). 1980 Jun;94(2):145-50. doi: 10.1530/acta.0.0940145.
Serum levels of gonadotrophins and prolactin and their response to luteinizing hormone/follicle stimulating hormone--releasing hormone (LRH) and thyrotrophin releasing hormone (TRH) were measured in 14 females with anorexia nervosa when at low body weight and again in 6 cases during, and 12 cases after weight gain. Mean serum luteinizing hormone (LH) and follicle-stimulating hormone (FSH) levels were low initially and whereas FSH increased significantly with weight gain, LH levels remained subnormal in most patients. LH responses to LRH were grossly impaired or absent in patients whose weight was below 75% of the ideal, but increased dramatically above this weight over-shadowing the more modest increase in FSH response. In three patients, however, impaired LH responses persisted as ideal weight was approached. Basal prolactin levels were well within the normal range in all patients. During weight gain there was no change in basal levels but the prolactin level 20 min after TRH was significantly increased.
对14名体重过低的神经性厌食症女性患者测定了促性腺激素和催乳素的血清水平及其对促黄体生成素/促卵泡激素释放激素（LRH）和促甲状腺激素释放激素（TRH）的反应，6例患者在体重增加期间以及12例患者在体重增加后再次进行了测定。血清促黄体生成素（LH）和促卵泡激素（FSH）的平均水平最初较低，虽然FSH随着体重增加而显著升高，但大多数患者的LH水平仍低于正常。体重低于理想体重75%的患者对LRH的LH反应严重受损或缺失，但体重超过此标准后LH反应急剧增加，超过了FSH反应较为适度的增加。然而，在三名患者中，随着接近理想体重，LH反应受损仍持续存在。所有患者的基础催乳素水平均在正常范围内。体重增加期间基础水平无变化，但TRH后20分钟的催乳素水平显著升高。
