Leeton J, McMaster R, Worsley A
Aust N Z J Obstet Gynaecol. 1978 Aug;18(3):194-7. doi: 10.1111/j.1479-828x.1978.tb00048.x.
Twenty women using oral contraception for a minimum of 2 years with no side effects volunteered to take part in this experiment which commenced after they had undergone laparoscopic sterilization. In a double-blind cross-over design, patients were administered either 1.0 mg ethynodiol diacetate + 0.1 mg mestranol ("Ovulen") each day for 21 days or an identical-looking placebo for the same number of days. The following month the alternative (cross-over) tablet was given. On days 12 and 25 of each cycle the women completed a modified form of Pitt's Depression Index and a short Sexual Response Score. The result indicated that the active pill ("Ovulen") was associated with a decreased sexual response, but with no increase in the depression index (relative to placebo). The significance of these findings is discussed in relation to previous work, the methodology of the study and hormone-behaviour experiments.
20名使用口服避孕药至少2年且无副作用的女性自愿参与了这项实验，该实验在她们接受腹腔镜绝育术后开始。在双盲交叉设计中，患者连续21天每天服用1.0毫克双醋炔诺醇+0.1毫克炔雌醇甲醚（“Ovulen”），或服用外观相同的安慰剂相同天数。接下来的一个月给予替代（交叉）片剂。在每个周期的第12天和第25天，这些女性完成了改良版的皮特抑郁指数和简短的性反应评分。结果表明，活性药丸（“Ovulen”）与性反应降低有关，但抑郁指数没有增加（相对于安慰剂）。结合之前的研究、本研究的方法以及激素与行为实验，讨论了这些发现的意义。
