Cho Hongbaek
Department of Biological Sciences, College of Natural Sciences, Sungkyunkwan University, Suwon, 16419, Republic of Korea.
J Microbiol. 2023 Mar;61(3):359-367. doi: 10.1007/s12275-023-00032-w. Epub 2023 Mar 23.
Bacterial cells are covered with various glycopolymers such as peptidoglycan (PG), lipopolysaccharides (LPS), teichoic acids, and capsules. Among these glycopolymers, PG assembly is the target of some of our most effective antibiotics, consistent with its essentiality and uniqueness to bacterial cells. Biosynthesis of other surface glycopolymers have also been acknowledged as potential targets for developing therapies to control bacterial infections, because of their importance for bacterial survival in the host environment. Moreover, biosynthesis of most surface glycopolymers are closely related to PG assembly because the same lipid carrier is shared for glycopolymer syntheses. In this review, I provide an overview of PG assembly and antibiotics that target this pathway. Then, I discuss the implications of a common lipid carrier being used for assembly of PG and other surface glycopolymers in antibiotic development.
细菌细胞表面覆盖着各种糖聚合物，如肽聚糖（PG）、脂多糖（LPS）、磷壁酸和荚膜。在这些糖聚合物中，PG组装是我们一些最有效的抗生素的作用靶点，这与其对细菌细胞的重要性和独特性相一致。其他表面糖聚合物的生物合成也被认为是开发控制细菌感染疗法的潜在靶点，因为它们对细菌在宿主环境中的存活至关重要。此外，大多数表面糖聚合物的生物合成与PG组装密切相关，因为糖聚合物合成共用相同的脂质载体。在这篇综述中，我概述了PG组装以及靶向该途径的抗生素。然后，我讨论了在抗生素开发中使用共同脂质载体进行PG和其他表面糖聚合物组装的意义。
