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Cross-β helical filaments of Tau and TMEM106B in gray and white matter of multiple system tauopathy with presenile dementia.

作者信息

Hoq Md Rejaul, Bharath Sakshibeedu R, Hallinan Grace I, Fernandez Anllely, Vago Frank S, Ozcan Kadir A, Li Daoyi, Garringer Holly J, Vidal Ruben, Ghetti Bernardino, Jiang Wen

机构信息

Department of Biological Sciences, Markey Center for Structural Biology, Purdue University, West Lafayette, IN, 47906, USA.

Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, 635 Barnhill Dr., MSB A136, Indianapolis, IN, 46202, USA.

出版信息

Acta Neuropathol. 2023 May;145(5):707-710. doi: 10.1007/s00401-023-02563-3. Epub 2023 Mar 23.

DOI:10.1007/s00401-023-02563-3
PMID:36952000
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10119215/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/944f/10119215/3c6e833a383a/401_2023_2563_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/944f/10119215/dc5dd0346ff0/401_2023_2563_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/944f/10119215/3c6e833a383a/401_2023_2563_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/944f/10119215/dc5dd0346ff0/401_2023_2563_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/944f/10119215/3c6e833a383a/401_2023_2563_Fig2_HTML.jpg

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本文引用的文献

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Age-dependent formation of TMEM106B amyloid filaments in human brains.人类大脑中 TMEM106B 淀粉样纤维的形成具有年龄依赖性。
Nature. 2022 May;605(7909):310-314. doi: 10.1038/s41586-022-04650-z. Epub 2022 Mar 28.
2
Structure-based classification of tauopathies.基于结构的tau 病分类。
Nature. 2021 Oct;598(7880):359-363. doi: 10.1038/s41586-021-03911-7. Epub 2021 Sep 29.
3
Structure of tau exon 10 splicing regulatory element RNA and destabilization by mutations of frontotemporal dementia and parkinsonism linked to chromosome 17.
Nat Struct Mol Biol. 2025 Mar 5. doi: 10.1038/s41594-025-01498-5.
4
TMEM106B C-terminal fragments aggregate and drive neurodegenerative proteinopathy in transgenic Caenorhabditis elegans.跨膜蛋白106B(TMEM106B)的C末端片段聚集并在转基因秀丽隐杆线虫中引发神经退行性蛋白病。
Alzheimers Dement. 2025 Feb;21(2):e14468. doi: 10.1002/alz.14468. Epub 2024 Dec 23.
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The Impact of HIV on Early Brain Aging-A Pathophysiological (Re)View.人类免疫缺陷病毒对早期大脑衰老的影响——病理生理学(再)审视
J Clin Med. 2024 Nov 21;13(23):7031. doi: 10.3390/jcm13237031.
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TMEM106B amyloid filaments in the Biondi bodies of ependymal cells.室管膜细胞的 Biondi 体中的 TMEM106B 淀粉样纤维。
Acta Neuropathol. 2024 Nov 6;148(1):60. doi: 10.1007/s00401-024-02807-w.
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TMEM106B C-terminal fragments aggregate and drive neurodegenerative proteinopathy.跨膜蛋白106B(TMEM106B)的C末端片段聚集并引发神经退行性蛋白病。
bioRxiv. 2024 Jun 11:2024.06.11.598478. doi: 10.1101/2024.06.11.598478.
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Cleaved TMEM106B forms amyloid aggregates in central and peripheral nervous systems.TMEM106B 经裂解后会在中枢和外周神经系统中形成淀粉样聚集物。
Acta Neuropathol Commun. 2024 Jun 17;12(1):99. doi: 10.1186/s40478-024-01813-z.
9
Cryo-EM structures of pathogenic fibrils and their impact on neurodegenerative disease research.致病性纤维的冷冻电镜结构及其对神经退行性疾病研究的影响。
Neuron. 2024 Jul 17;112(14):2269-2288. doi: 10.1016/j.neuron.2024.05.012. Epub 2024 Jun 3.
10
Tau filaments with the Alzheimer fold in cases with mutations V337M and R406W.在携带V337M和R406W突变的病例中具有阿尔茨海默折叠的tau细丝。
bioRxiv. 2024 Apr 30:2024.04.29.591661. doi: 10.1101/2024.04.29.591661.
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Proc Natl Acad Sci U S A. 1999 Jul 6;96(14):8229-34. doi: 10.1073/pnas.96.14.8229.
4
Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17.tau基因错义突变及5'-剪接位点突变与遗传性痴呆FTDP-17的关联
Nature. 1998 Jun 18;393(6686):702-5. doi: 10.1038/31508.
5
Mutation in the tau gene in familial multiple system tauopathy with presenile dementia.伴有早老性痴呆的家族性多系统tau蛋白病中tau基因的突变
Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7737-41. doi: 10.1073/pnas.95.13.7737.
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Familial multiple system tauopathy with presenile dementia: a disease with abundant neuronal and glial tau filaments.伴有早老性痴呆的家族性多系统tau蛋白病:一种具有大量神经元和胶质tau蛋白细丝的疾病。
Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):4113-8. doi: 10.1073/pnas.94.8.4113.
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Expression of separate isoforms of human tau protein: correlation with the tau pattern in brain and effects on tubulin polymerization.人tau蛋白不同亚型的表达:与脑中tau模式的相关性及对微管蛋白聚合的影响。
EMBO J. 1990 Dec;9(13):4225-30. doi: 10.1002/j.1460-2075.1990.tb07870.x.