核孔蛋白 107 是与免疫浸润相关的肝细胞癌的预后生物标志物。
Nucleoporin 107 is a prognostic biomarker in hepatocellular carcinoma associated with immune infiltration.
机构信息
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, People's Republic of China.
Key Laboratory of Early Prevention & Treatment for Regional High Frequency Tumor, Ministry of Education, Guangxi Medical University, Nanning, People's Republic of China.
出版信息
Cancer Med. 2023 May;12(9):10990-11009. doi: 10.1002/cam4.5807. Epub 2023 Mar 23.
OBJECTIVE
To assess the diagnostic value and clinical significance of nucleoporin 107 (NUP107) in hepatocellular carcinoma (HCC), and explore the possible mechanisms.
METHODS
The transcriptomic and clinical data of HCC patients were retrieved from The Cancer Genome Atlas (TCGA) and GEO databases. Tissue specimens were collected from HCC patients in the Guangxi area. According to the expression levels and prognostic characteristics of NUP107, ROC curves and nomogram models were constructed using the R package.
RESULTS
NUP107 was highly expressed in 26 human cancers including HCC, and was associated with advanced HCC staging and worse prognosis. NUP107 showed satisfactory ability to predict the prognosis of HCC patients (AUC >0.8). Results of gene set enrichment analysis (GSEA) further showed that NUP107 was mainly associated with cell cycle-related pathways such as the cell cycle, DNA replication, G2M checkpoint, E2F target, and mitotic spindle. In addition, NUP107 was also associated with immune infiltration in HCC and showed significant positive correlation with immune checkpoints (PD-L1 and TIM-3).
目的
评估核孔蛋白 107（NUP107）在肝细胞癌（HCC）中的诊断价值和临床意义，并探讨其可能的机制。
方法
从癌症基因组图谱（TCGA）和 GEO 数据库中检索 HCC 患者的转录组学和临床数据。收集广西地区 HCC 患者的组织标本。根据 NUP107 的表达水平和预后特征，使用 R 包构建 ROC 曲线和列线图模型。
结果
NUP107 在包括 HCC 在内的 26 种人类癌症中高表达，与 HCC 的晚期分期和较差的预后相关。NUP107 对 HCC 患者的预后具有良好的预测能力（AUC＞0.8）。基因集富集分析（GSEA）的结果进一步表明，NUP107 主要与细胞周期相关途径相关，如细胞周期、DNA 复制、G2M 检查点、E2F 靶标和有丝分裂纺锤体。此外，NUP107 还与 HCC 中的免疫浸润相关，并与免疫检查点（PD-L1 和 TIM-3）呈显著正相关。
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