趋化因子与癌症的免疫反应。
Chemokines and the immune response to cancer.
机构信息
Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Center for Immunology & Inflammatory Diseases, Division of Rheumatology, Allergy & Immunology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
出版信息
Immunity. 2021 May 11;54(5):859-874. doi: 10.1016/j.immuni.2021.01.012. Epub 2021 Apr 10.
Abstract
Chemokines are chemotactic cytokines that regulate the migration of immune cells. Chemokines function as cues for the coordinated recruitment of immune cells into and out of tissue and also guide the spatial organization and cellular interactions of immune cells within tissues. Chemokines are critical in directing immune cell migration necessary to mount and then deliver an effective anti-tumor immune response; however, chemokines also participate in the generation and recruitment of immune cells that contribute to a pro-tumorigenic microenvironment. Here, we review the role of the chemokine system in anti-tumor and pro-tumor immune responses and discuss how malignant cells and the tumor microenvironment regulate the overall chemokine landscape to shape the type and outcome of immune responses to cancer and cancer treatment.
摘要
趋化因子是趋化细胞因子，可调节免疫细胞的迁移。趋化因子作为免疫细胞在组织内外协调募集的信号，指导免疫细胞在组织内的空间组织和细胞相互作用。趋化因子在指导免疫细胞迁移中起着关键作用，这些迁移对于产生和传递有效的抗肿瘤免疫反应是必需的；然而，趋化因子也参与了促进肿瘤发生的微环境中免疫细胞的产生和募集。在这里，我们综述了趋化因子系统在抗肿瘤和促肿瘤免疫反应中的作用，并讨论了恶性细胞和肿瘤微环境如何调节整体趋化因子景观，以塑造对癌症和癌症治疗的免疫反应的类型和结果。
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