撒哈拉以南非洲地区艾滋病毒感染者心电图异常的研究综述：系统评价。

Review of electrocardiographic abnormalities among people living with HIV in Sub-Saharan Africa: A systematic review.

机构信息

Department of Medicine, Lung Institute, College of Health Sciences, Makerere University, Kampala, Uganda.

Department of Physiology, School of Biomedical Sciences, College of Health Sciences, Makerere University, Kampala, Uganda.

出版信息

PLoS One. 2023 Mar 23;18(3):e0283419. doi: 10.1371/journal.pone.0283419. eCollection 2023.

DOI:10.1371/journal.pone.0283419

PMID:36952493

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10035850/

Abstract

INTRODUCTION

Electrocardiographic (ECG) abnormalities are increasingly being reported among people living with HIV (PLWH). However, the exact prevalence of ECG abnormalities among PLWH in Sub-Saharan Africa (SSA), a region with one of the highest burdens of HIV, is not known. Through a systematic review, we determined the prevalence and patterns of ECG abnormalities among PLWH in SSA.

METHODS

We conducted a search in online databases including EMBASE, MEDLINE, CINAHL and Research for Life for studies published between 1st January 2000 and 31st December 2020. Studies reporting any form of ECG abnormalities published in English were screened and reviewed for eligibility. Retrieved studies were assessed for validity using the modified Newcastle-Ottawa Scale. Data was summarized qualitatively, and ECG abnormalities were further subcategorized into rate, conduction, and rhythm abnormalities as well as atrial and ventricular enlargements.

RESULTS

We retrieved seventeen of the 219 studies assessed for eligibility published between 2001 and 2020, with a total of 2,572 eligible participants. The mean age of the participants ranged between 6.8 years and 58.6 years. Of the 17 studies, 8 (47%) were case-control, 6 (35.3%) cross-sectional and 3 (17.6%) were cohort in design. Thirteen studies were conducted in the adult population while four were conducted in the pediatric population. The prevalence of ECG abnormalities ranged from 10% to 81% and 6.7% to 26.5% in the adult and pediatric population respectively. Among studies done in the adult population, conduction abnormalities were the most reported (9 studies) with a prevalence ranging from 3.4% to 53.5%. In the pediatric population, rate abnormalities were the most reported (4 studies) with a prevalence ranging from 3.9% to 20.9%. The heterogeneity in results could be attributed to the absence of uniform criteria to define ECG abnormalities.

CONCLUSION

Our findings highlight a high prevalence of ECG abnormalities among PLWH in SSA. Consideration of ECG in the comprehensive evaluation of cardiac dysfunction among PLWH in SSA maybe warranted.

摘要

简介

心电图（ECG）异常在艾滋病毒感染者（PLWH）中越来越常见。然而，在撒哈拉以南非洲（SSA）这一 HIV 负担最重的地区之一，PLWH 中 ECG 异常的确切患病率尚不清楚。通过系统评价，我们确定了 SSA 中 PLWH 中 ECG 异常的患病率和模式。

方法

我们在在线数据库中进行了搜索，包括 EMBASE、MEDLINE、CINAHL 和 Research for Life，检索了 2000 年 1 月 1 日至 2020 年 12 月 31 日期间发表的研究。筛选并审查了以英文发表的任何形式 ECG 异常的研究，以确定其合格性。使用改良的 Newcastle-Ottawa 量表评估检索到的研究的有效性。定性总结数据，并将 ECG 异常进一步细分为心率、传导和节律异常以及心房和心室扩大。

结果

我们从 2001 年至 2020 年期间评估的 219 项符合条件的研究中检索到 17 项，共有 2572 名合格参与者。参与者的平均年龄范围在 6.8 岁至 58.6 岁之间。在这 17 项研究中，8 项（47%）为病例对照研究，6 项（35.3%）为横断面研究，3 项（17.6%）为队列研究。13 项研究在成年人群中进行，4 项在儿科人群中进行。心电图异常的患病率在成年人群中为 10%至 81%，在儿科人群中为 6.7%至 26.5%。在成人人群中进行的研究中，传导异常的报告最多（9 项研究），患病率为 3.4%至 53.5%。在儿科人群中，心率异常的报告最多（4 项研究），患病率为 3.9%至 20.9%。结果的异质性可能归因于缺乏统一的标准来定义心电图异常。