Pham Duy T, Scholman H J, Mercks C
Univers-Augenklinik.
Klin Monbl Augenheilkd. 1987 Oct;191(4):310-3.
The present paper communicates clinical and pathohistologic findings in a case of carcinoma in situ of the conjunctiva (Bowen's disease) with a five-year course. Initially, there are clinical similarities between Bowen's disease and Mooren's ulcer; the diagnosis can be established on the basis of the histologic findings. In this case the clinical picture at first resembled that of Mooren's ulcer. An epithelial dysplasia was confirmed histologically following perilimbal conjunctivectomy. A year later the dysplasia was found to have progressed and was treated by diathermy coagulation. At the check-up examination three months later the tumor had diminished in size. Four years later, however, it had redeveloped. As a rule, tumor excision is the treatment of choice. In the case described here it was first coagulated by diathermy because of its great extent, but this only brought the tumor to a temporary standstill.
本文报道了一例病程长达五年的结膜原位癌(鲍恩病)的临床及病理组织学 findings。起初,鲍恩病与蚕蚀性角膜溃疡在临床上有相似之处;诊断可基于组织学 findings 来确立。在此病例中,最初的临床表现类似于蚕蚀性角膜溃疡。在进行角膜缘结膜切除术后,组织学检查证实存在上皮发育异常。一年后,发现发育异常有所进展,遂采用透热凝固法进行治疗。三个月后的复查中,肿瘤体积缩小。然而,四年后肿瘤复发。通常,肿瘤切除是首选的治疗方法。在此病例中,由于肿瘤范围较大,最初采用透热凝固法进行治疗,但这仅使肿瘤暂时停止发展。