Cullen J M, Levine J F
Department of Microbiology, Parasitology and Pathology, North Carolina State University, School of Veterinary Medicine, Raleigh 27606.
Lab Anim Sci. 1987 Oct;37(5):640-3.
Pathologic changes produced after 4 weeks of infection by Babesia microti in Syrian hamsters are described and compared to babesiosis of humans. Following intraperitoneal inoculation, both intravascular and extravascular hemolysis developed. Up to 70% of red blood cells were parasitized. The principal morphologic abnormalities were an increase in extramedullary hematopoiesis and hyperplasia of the mononuclear phagocytic cells of the red pulp manifested grossly as splenomegaly, marked renal tubular hemosiderosis and hypertrophy of Kupffer cells. The disease was not fatal to any hamsters during the 4 week study. The clinical signs and lesions were less severe than fatal babesiosis of asplenic humans and similar to severe, but nonfatal disease in spleen intact humans. The hamster may serve as an animal model for the studying the pathophysiology of human babesiosis and for studying potential chemotherapeutic agents.
描述了微小巴贝斯虫感染叙利亚仓鼠4周后产生的病理变化，并与人类巴贝斯虫病进行了比较。腹腔接种后，出现了血管内和血管外溶血。高达70%的红细胞被寄生。主要的形态学异常是髓外造血增加和红髓单核吞噬细胞增生，肉眼表现为脾肿大、明显的肾小管含铁血黄素沉着和库普弗细胞肥大。在4周的研究中，该疾病对任何仓鼠都不致命。临床症状和病变比无脾人类的致命巴贝斯虫病轻，与脾完整人类的严重但非致命疾病相似。仓鼠可作为研究人类巴贝斯虫病病理生理学和研究潜在化疗药物的动物模型。
