Roher D P, Anderson J F, Nielsen S W
Am J Vet Res. 1985 Jan;46(1):256-62.
One splenectomized and 6 intact coyotes (Canis latrans), and 2 coydogs were experimentally inoculated with a recent isolate of Babesia gibsoni. The disease was mild in intact animals, was fatal in the splenectomized coyote, and was characterized by a regenerative hemolytic anemia with the PCV decreasing to 16% in intact animals and to 6% in the splenectomized coyote. Peak parasitemia ranged from 3% to 21% of erythrocytes infected and was inversely correlated to PCV. Serum lactate dehydrogenase, bilirubin, and globulin concentrations were increased in all infected animals. Three weeks after inoculation, specific antibody titers increased to 1:65,536 and remained elevated in the chronically infected animals. The splenectomized coyote had progressive weakness until death, 24 days after inoculation. Intact animals had splenomegaly and anorexia at the height of infection. The splenectomized coyote had generalized edema, omental petechiae, renal and hepatic degeneration, membrano-proliferative glomerulonephritis and congestion, extramedullary hematopoiesis, lymphoid hyperplasia, and severe hemosiderosis in an accessory spleen. The only consistent change in the intact animals was splenomegaly.
将1只脾切除的郊狼和6只健康的郊狼（犬属）以及2只郊狼犬用最近分离出的吉氏巴贝斯虫进行实验性接种。在健康动物中疾病症状较轻，在脾切除的郊狼中则是致命的，其特征为再生性溶血性贫血，健康动物的红细胞压积降至16%，脾切除的郊狼降至6%。最高寄生虫血症范围为感染红细胞的3%至21%，且与红细胞压积呈负相关。所有感染动物的血清乳酸脱氢酶、胆红素和球蛋白浓度均升高。接种三周后，特异性抗体滴度升至1:65,536，并在慢性感染动物中持续升高。脾切除的郊狼逐渐虚弱，直至接种后24天死亡。健康动物在感染高峰期出现脾肿大和厌食。脾切除的郊狼出现全身性水肿、网膜瘀点、肾和肝变性、膜增生性肾小球肾炎和充血、髓外造血、淋巴样增生以及副脾严重含铁血黄素沉着。健康动物唯一持续出现的变化是脾肿大。
