Fabris G, Marchetti E, Marzola A, Bagni A, Querzoli P, Nenci I
Istituto di Anatomia e Istologia Patologica, Università di Ferrara, Italy.
J Steroid Biochem. 1987;27(1-3):171-6. doi: 10.1016/0022-4731(87)90307-4.
Identification of preneoplastic lesions of the breast has mainly rested on morphological grounds, supported by epidemiological data. These studies assign a definite precancerous potential to a group of atypical hyperplastic lesions and in situ carcinoma. In spite of much effort no criteria are yet available to understand which, among these lesions, is committed to infiltrative growth, in other words, to understand the risk to a single patient. Estrogens are know to play a critical role in the etiology of breast cancer. The hypothesis is investigated that this role is dependent on a modified expression of their receptor. To approach this question estrogen receptor expression was traced by specific monoclonal anti-receptor antibodies and immunocytochemistry, on a spectrum of breast tissue changes, from normal tissue to infiltrating cancer. Estrogen receptor expression is heterogeneous in normal tissue and in infiltrating cancer, and on the contrary is homogeneous in proliferative atypical lesions and in in situ carcinomas. Present results show that receptor expression is enhanced and becomes homogeneous, maybe constitutive, in atypical hyperplasia and in in situ carcinoma and that this phenomenon could subserve important changes of proliferative capacity which are necessary and possibly sufficient for autonomous growth.
乳腺肿瘤前病变的识别主要基于形态学依据，并得到流行病学数据的支持。这些研究赋予了一组非典型增生性病变和原位癌明确的癌前潜能。尽管付出了很多努力，但仍没有标准来确定这些病变中哪些会发展为浸润性生长，换句话说，无法确定单个患者的风险。已知雌激素在乳腺癌病因中起关键作用。有人研究了这样一种假说，即这种作用取决于其受体的表达改变。为解决这个问题，通过特异性单克隆抗受体抗体和免疫细胞化学方法，追踪了从正常组织到浸润性癌一系列乳腺组织变化中的雌激素受体表达情况。雌激素受体表达在正常组织和浸润性癌中是异质性的，而在增殖性非典型病变和原位癌中则是均匀的。目前的结果表明，在非典型增生和原位癌中，受体表达增强并变得均匀，可能是组成性的，而且这种现象可能有助于增殖能力发生重要变化，而这种变化对于自主生长是必要的，甚至可能是充分的。
