Schmitt F C
IPATIMUP, Laboratório de Anatomia Patológica, Faculdade de Medicina, Hospital de São João, Porto, Portugal.
Eur J Cancer. 1995 Nov;31A(12):2049-52. doi: 10.1016/0959-8049(95)00430-0.
We investigated the relationship between hormone receptor status and cellular proliferation in a series of proliferative epithelial breast lesions in an attempt to clarify the putative role of this interaction in the process of breast carcinogenesis. The separation of oestrogen receptor (ER) positive and ER negative cases revealed that in hyperplastic breast epithelium (with and without atypia) the ER positive cases had a higher proliferation rate than that of ER negative cases. Conversely, in ductal carcinomas (both in situ and invasive), ER negative cases had rates of proliferation higher than those observed among the ER positive cases. The observation of higher proliferation in ER positive benign proliferative breast lesions fits with the concept of an initial hormone-dependent status in breast carcinogenesis. According to this assumption, activation of ER by hormone increases the possibility that cells may undergo malignant transformation. Although we are limited by our static view of the process, our results point to the existence of successive steps of progression from a hormone-dependent towards an autonomous growth. The demonstration of higher proliferation in ER-negative carcinomas, from the in situ phase onwards, reinforces the hypothesis that breast cancer progression is paralleled by a progressive hormone independence.
我们研究了一系列增殖性乳腺上皮病变中激素受体状态与细胞增殖之间的关系，试图阐明这种相互作用在乳腺癌发生过程中假定的作用。雌激素受体（ER）阳性和阴性病例的区分显示，在增生性乳腺上皮（有或无非典型性）中，ER阳性病例的增殖率高于ER阴性病例。相反，在导管癌（原位癌和浸润癌）中，ER阴性病例的增殖率高于ER阳性病例中观察到的增殖率。ER阳性良性增殖性乳腺病变中较高增殖率的观察结果与乳腺癌发生中初始激素依赖性状态的概念相符。根据这一假设，激素对ER的激活增加了细胞可能发生恶性转化的可能性。尽管我们受限于对该过程的静态看法，但我们的结果表明存在从激素依赖性向自主生长的连续进展步骤。从原位阶段起，ER阴性癌中较高增殖率的证明强化了这样的假设，即乳腺癌进展与逐渐的激素非依赖性并行。
