Carlstedt-Duke J, Gustafsson J A
Department of Medical Nutrition, Karolinska Institute, Huddinge University Hospital, Sweden.
J Steroid Biochem. 1987;27(1-3):99-104. doi: 10.1016/0022-4731(87)90299-8.
The glucocorticoid receptor protein is a transcriptional regulatory protein that interacts with specific enhancer sequences. A stoichiometric analysis of the interaction indicates an equimolar relationship between the receptor protein and the specific enhancer sequences. The activity of the receptor protein is itself regulated by the binding of glucocorticoids. The two functional domains (DNA-binding and steroid-binding) are adjacent and lie within the C-terminal half of the receptor protein. The N-terminal half of the protein appears to modulate the interaction with DNA but does not have any role in the binding of the steroid. The functional domains have also been defined at the sequence level.
糖皮质激素受体蛋白是一种与特定增强子序列相互作用的转录调节蛋白。对这种相互作用的化学计量分析表明，受体蛋白与特定增强子序列之间存在等摩尔关系。受体蛋白的活性本身受糖皮质激素结合的调节。两个功能结构域（DNA结合结构域和类固醇结合结构域）相邻，位于受体蛋白的C端一半区域内。该蛋白的N端一半区域似乎可调节与DNA的相互作用，但在类固醇结合中不起任何作用。这些功能结构域在序列水平上也已得到明确。
