一种用于兔反复脑脊液穿刺的储液器模型。

A reservoir model for repeated CSF access in the rabbit.

作者信息

Samphilipo M A, Hassenbusch S J, Grochow L B, Starr F L, Anderson J H

机构信息

Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.

出版信息

J Neurosci Methods. 1987 Nov;22(1):47-52. doi: 10.1016/0165-0270(87)90088-4.

DOI:10.1016/0165-0270(87)90088-4

PMID:3695567

Abstract

A simple, reliable and inexpensive subcutaneously implanted reservoir-catheter system method was developed for repeated sterile access to the rabbit brain ventricular system. The system provides an avenue for the repeated intrathecal administration of drugs and for the withdrawal of cerebrospinal fluid (CSF). Reservoirs were subcutaneously implanted under the scalp and connected to tubing inserted into the cisterna magna or the lateral ventricle. The systems successfully functioned in 38 of 41 animals (12 with cisternal magna catheters and 29 with lateral ventricle catheters), for up to 12 weeks following implantation. Patency of the systems were documented with X-rays and radiopaque injected contrast medium.

摘要

开发了一种简单、可靠且廉价的皮下植入储液器-导管系统方法，用于反复无菌进入兔脑室系统。该系统为药物的反复鞘内给药和脑脊液（CSF）的抽取提供了途径。储液器皮下植入头皮下，并与插入枕大池或侧脑室的导管相连。在41只动物中，有38只（12只植入枕大池导管，29只植入侧脑室导管）的系统成功运行，植入后长达12周。通过X射线和注入不透射线的造影剂记录系统的通畅情况。