Wood J H, Poplack D G, Flor W J, Gunby E N, Ommaya A K
Neurosurgery. 1977 Sep-Oct;1(2):132-5. doi: 10.1227/00006123-197709000-00009.
Animal models enabling reliable access to ventricular cerebrospinal fluid (CSF) are crucial to the study of neuropharmacological and neurotoxicological effects of cytotoxic agents used to treat central nervous system neoplasms. This investigation concludes that 4th ventricular catheterization using subcutaneous CSF reservoirs in rhesus monkeys: (a) provides chronic access to sterile CSF without chronic immobilization, (b) enables mixing of injected drugs with lateral ventricular CSF, (c) permits sensitive monitoring of intraventricular pressure and (d) does not produce tissue damage during cannula implantation or breakdown of the blood-brain barrier.
能够可靠获取脑室脑脊液（CSF）的动物模型对于研究用于治疗中枢神经系统肿瘤的细胞毒性药物的神经药理学和神经毒理学作用至关重要。本研究得出结论，在恒河猴中使用皮下脑脊液储液器进行第四脑室插管：（a）无需长期固定即可长期获取无菌脑脊液，（b）能使注入的药物与侧脑室脑脊液混合，（c）允许对脑室内压力进行灵敏监测，以及（d）在插管植入过程中不会产生组织损伤或血脑屏障破坏。
