Liu Jiaying, Song Linlin, Zhan Jing, Zhong Yunxin, Shi Zhixiong
Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing 100193, China.
School of Public Health and Beijing Key Laboratory of Environmental Toxicology, Capital Medical University, Beijing 100069, China.
Sci Total Environ. 2023 Jun 20;878:162988. doi: 10.1016/j.scitotenv.2023.162988. Epub 2023 Mar 22.
High exposure of per- and polyfluoroalkyl substances (PFAS) has been reported in main chemical production areas in China, while epidemiological study on exposure risk of PFAS is still limited. In this study, legacy and alternative PFAS were measured in serum samples from 161 adults living in Laizhou Bay, a famous chemical production area located in Shandong province, Northern China. Based on the concentrations of serum PFAS, the disrupting effects of PFAS on serum lipids and thyroid function were further explored. The results showed that the serum perfluorooctanoic acid (PFOA) (geometric mean (GM): 60 ng/mL) in this region was even higher than serum PFOA of residents living in PFOA contaminated water districts in United States and Sweden. 100 % of the serum PFOA was higher than the reference dose for increased total cholesterol (TC). Consistently, higher serum PFOA was marginally correlated with increased TC level (p = 0.062) and low-density lipoprotein (p = 0.065). In addition, higher perfluoroisopropyl perfluorooctanesulfonate and 6:2 chlorinated polyfluoroalkyl ether sulfonates (6,2 Cl-PFESA) were significantly correlated with increased high-density lipoprotein (p = 0.040, 0.022). No significant association was observed between individual PFAS and any thyroid function biomarker. However, using the principal component analysis derived factors to represent the co-exposure patterns, co-exposure of legacy long-chain PFAS showed synergistic effects on the free thyroxine, while the mixture of alternative PFAS showed a synergistic influence on the total and free triiodothyronine.
据报道，中国主要化工产区的全氟和多氟烷基物质（PFAS）暴露水平较高，而关于PFAS暴露风险的流行病学研究仍然有限。在本研究中，对居住在中国北方山东省著名化工产区莱州湾的161名成年人的血清样本中的传统和替代PFAS进行了测量。基于血清PFAS的浓度，进一步探讨了PFAS对血清脂质和甲状腺功能的干扰作用。结果表明，该地区血清全氟辛酸（PFOA）（几何均值（GM）：60 ng/mL）甚至高于美国和瑞典生活在受PFOA污染水区居民的血清PFOA。100%的血清PFOA高于总胆固醇（TC）升高的参考剂量。一致地，较高的血清PFOA与TC水平升高（p = 0.062）和低密度脂蛋白（p = 0.065）呈微弱相关。此外，较高的全氟异丙基全氟辛烷磺酸和6:2氯代多氟烷基醚磺酸盐（6,2 Cl-PFESA）与高密度脂蛋白升高显著相关（p = 0.040，0.022）。未观察到单个PFAS与任何甲状腺功能生物标志物之间存在显著关联。然而，使用主成分分析得出的因素来代表共同暴露模式时，传统长链PFAS的共同暴露对游离甲状腺素显示出协同作用，而替代PFAS的混合物对总三碘甲状腺原氨酸和游离三碘甲状腺原氨酸显示出协同影响。
