School of Environment and Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, China.
Ministry of Education-Shanghai Key Laboratory of Children's Environmental Health, Xinhua Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200092, China.
Environ Sci Technol. 2022 May 17;56(10):6172-6181. doi: 10.1021/acs.est.1c07422. Epub 2022 Jan 12.
Exploration of the exposure of preconception couples to per- and polyfluoroalkyl substances (PFAS), as well as the most important influencing factors, promotes the understanding of the joint effects of parental exposure on reproductive health. In the present study, a total of 938 preconception couples recruited through the Shanghai Birth Cohort were investigated for the variations of PFAS exposure and contributing factors within and between couples. While linear perfluorooctanoic acid (n-PFOA, median 20.4 ng/mL) and linear perfluorooctanesulfonic acid (n-PFOS, 12.1 ng/mL) remained dominant in plasma, emerging PFAS, particularly 6:2 chlorinated polyfluorinated ether sulfonate (10.5 ng/mL), 6:2 polyfluoroalkyl phosphate diester (0.41 ng/mL), and branched PFOS or PFOA isomers, were also frequently detected. Although individual PFAS were generally correlated within couples, gender differences significantly existed in the concentrations of most individual PFAS and isomer profiles of PFOS and PFOA. Men generally exhibited higher plasma concentrations than their partners, likely reflecting gender-specific elimination pathway and kinetics. Couple-based PFAS exposure also varied greatly. After adjustment for individual factors, several household factors, including annual household income, dwelling floor type, drinking water source, and living near farmlands, were found to be associated with couple-based PFAS exposure. Our study constitutes one of the few studies addressing couple-based exposure to PFAS and lays a solid ground for further assessment of the impacts of parental exposure on reproductive health.
探讨孕前夫妇接触全氟和多氟烷基物质（PFAS）的情况，以及最重要的影响因素，有助于了解父母双方暴露对生殖健康的联合影响。本研究通过上海出生队列共调查了 938 对孕前夫妇，以探讨夫妇内和夫妇间 PFAS 暴露的变化及其影响因素。虽然血浆中仍以线性全氟辛烷磺酸（n-PFOS，中位数 12.1ng/mL）和线性全氟辛酸（n-PFOA，中位数 20.4ng/mL）为主，但新兴的 PFAS，特别是 6:2 氯代全氟醚磺酸（10.5ng/mL）、6:2 多氟烷基磷酸酯二酯（0.41ng/mL）和支链 PFOS 或 PFOA 异构体，也经常被检测到。虽然夫妇内个体 PFAS 通常相互关联，但大多数个体 PFAS 的浓度和 PFOS 和 PFOA 的异构体分布存在显著的性别差异。男性的血浆浓度普遍高于其伴侣，这可能反映了性别特异性的消除途径和动力学。夫妇间的 PFAS 暴露也存在很大差异。在调整个体因素后，一些家庭因素，包括家庭年收入、住房楼层类型、饮用水源和居住在农田附近，与夫妇间 PFAS 暴露有关。本研究是少数几篇探讨夫妇间 PFAS 暴露的研究之一，为进一步评估父母双方暴露对生殖健康的影响奠定了坚实的基础。
