Hu Liehai, Zhao Yu, You Tao, Xu Hengyi
State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China.
J Appl Microbiol. 2023 Apr 3;134(4). doi: 10.1093/jambio/lxad061.
Lead (Pb) is a toxic heavy metal that has been intensively studied, but its toxicity in sub-healthy people remains unclear. This study aims to investigate the adverse effects of Pb in the obese population and validate the feasibility of a potential probiotic strain for the treatment of Pb poisoning and diet-induced obesity.
Male Kunming mice were fed a high-fat/high-sugar (HFHS) diet for 6 weeks, then received Pb exposure and Lactiplantibacillus plantarum P101 supplementation for 2 weeks. The histopathology of the liver and colon was observed, and biochemical indicators and gene expression levels were measured.
Here, we reported that Pb exposure exacerbated the existing oxidative stress and gut barrier injury in obese mice, leading to more severe Pb accumulation, and hepatic inflammatory injury compared with normal diet-fed mice. It is worth noting that the P101 treatment significantly reduced Pb accumulation by promoting fecal Pb excretion and enhanced the antioxidant capacity of mice. After P101 treatment, obesity-related indicators were downregulated, and the hepatic injury and gut barrier disruption in mice were alleviated effectively.
铅（Pb）是一种已被深入研究的有毒重金属，但其对亚健康人群的毒性仍不清楚。本研究旨在调查铅对肥胖人群的不良影响，并验证一种潜在益生菌菌株治疗铅中毒和饮食诱导肥胖的可行性。
雄性昆明小鼠喂食高脂/高糖（HFHS）饮食6周，然后接受铅暴露和植物乳杆菌P101补充剂处理2周。观察肝脏和结肠的组织病理学，测量生化指标和基因表达水平。
在此，我们报告铅暴露加剧了肥胖小鼠现有的氧化应激和肠道屏障损伤，导致与正常饮食喂养小鼠相比更严重的铅蓄积和肝脏炎症损伤。值得注意的是，P101处理通过促进粪便铅排泄显著降低了铅蓄积，并增强了小鼠的抗氧化能力。P101处理后，肥胖相关指标下调，小鼠的肝脏损伤和肠道屏障破坏得到有效缓解。
