美国心脏协会的“生活简单7要素”与PREDIMED研究队列中的心房颤动风险
American Heart Association's life simple 7 and the risk of atrial fibrillation in the PREDIMED study cohort.
作者信息
Díaz-Gutiérrez Jesús, Martínez-González Miguel Ángel, Alonso Alvaro, Toledo Estefanía, Salas-Salvadó Jordi, Sorlí Jose V, Ros Emilio, Fitó Montse, Estruch Ramón, Arós Fernando, Fiol Miquel, Lapetra José, Gómez-Gracia Enrique, Serra-Majem Lluis, Pintó Xavier, Portolés Olga, Babio Nancy, Castañer Olga, Ruiz-Canela Miguel
机构信息
Department of Cardiology, University Hospital Juan Ramón Jiménez, Huelva, Spain; Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, IdiSNA, Pamplona, Spain.
Department of Preventive Medicine and Public Health, School of Medicine, University of Navarra, IdiSNA, Pamplona, Spain; Consorcio CIBER, M.P. Fisiopatología de la Obesidad y Nutrición (CIBERObn), Instituto de Salud Carlos III (ISCIII), Madrid, Spain; Department of Nutrition, Harvard TH Chan School of Public Health, Boston, MA, United States.
出版信息
Nutr Metab Cardiovasc Dis. 2023 Jun;33(6):1144-1148. doi: 10.1016/j.numecd.2023.02.004. Epub 2023 Feb 16.
BACKGROUND AND AIMS
The American Heart Association proposed 7 ideal cardiovascular health metrics (Life's Simple 7 [LS7]) namely, not smoking, body mass index <25 kg/m, healthy diet, moderate physical activity ≥150 min/week, total blood cholesterol <200 mg/dL, blood pressure <120/80 mmHg and fasting blood glucose <100 mg/dL. Our objective was to assess the association between these LS7 metrics and the incidence of atrial fibrillation (AF).
METHODS AND RESULTS
A total of 6,479 participants of the PREDIMED study were included. We calculated the participants' baseline LS7 index ranging 0-7 points to categorize them according to their adherence to these LS7 health metrics. Multivariable Cox regression models were used to estimate Hazard Ratios (HR) and their 95% Confidence Intervals (95% CI). After a median follow-up of 4.8 years, we identified 250 incident cases of AF. After adjusting for potential confounders, adherence to LS7 index was not associated with the incidence of AF (adjusted HR 0.90 [95% CI: 0.56-1.45] for highest vs. lowest LS7 categories). Body mass index <25 kg/m was the only health metric individually associated with a lower risk of AF (HR 0.36 [95% CI: 0.16-0.78]).
CONCLUSIONS
In a high cardiovascular risk Spanish population, adherence to American Heart Association's LS7 metrics was not associated with the risk of incident AF.
CLINICAL TRIALS NUMBER
ISRCTN35739639.
背景与目的
美国心脏协会提出了7项理想的心血管健康指标（即“生活简单7要素”[LS7]），分别为不吸烟、体重指数<25kg/m²、健康饮食、中等强度体育活动≥150分钟/周、总血胆固醇<200mg/dL、血压<120/80mmHg以及空腹血糖<100mg/dL。我们的目的是评估这些LS7指标与心房颤动（AF）发病率之间的关联。
方法与结果
纳入了PREDIMED研究的6479名参与者。我们计算了参与者的基线LS7指数，范围为0至7分，以便根据他们对这些LS7健康指标的遵守情况进行分类。使用多变量Cox回归模型来估计风险比（HR）及其95%置信区间（95%CI）。在中位随访4.8年后，我们确定了250例AF新发病例。在对潜在混杂因素进行调整后，遵守LS7指数与AF发病率无关（最高与最低LS7类别相比，调整后的HR为0.90[95%CI：0.56 - 1.45]）。体重指数<25kg/m²是唯一一项与较低AF风险单独相关的健康指标（HR为0.36[95%CI：0.16 - 0.78]）。
结论
在心血管风险较高的西班牙人群中，遵守美国心脏协会的LS7指标与AF发病风险无关。
临床试验编号
ISRCTN35739639。
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