T 细胞 TET2 缺失消除抗肿瘤 CAR T 细胞治疗的障碍。
T cell TET2 disruption cuts the breaks on antitumor CAR T cell therapy.
机构信息
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA; Department of Bone Marrow Transplantation and Cellular Therapy, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
Department of Immunology, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Trends Immunol. 2023 Jun;44(6):397-398. doi: 10.1016/j.it.2023.03.008. Epub 2023 Mar 21.
Functional persistence of chimeric antigen receptor (CAR) T cells is required for sustaining an antitumor response. Recently, Jain et al. revealed that disruption of TET2 in CAR T cells resulted in antigen-independent CAR T cell hyperproliferation that enhanced tumor control in mice, highlighting the potential of epigenetic strategies to improve T cell-based cancer immunotherapy.
嵌合抗原受体 (CAR) T 细胞的功能持久性是维持抗肿瘤反应所必需的。最近，Jain 等人揭示了 CAR T 细胞中 TET2 的破坏导致了抗原非依赖性的 CAR T 细胞过度增殖，从而增强了小鼠的肿瘤控制，这凸显了表观遗传策略在改善基于 T 细胞的癌症免疫疗法方面的潜力。
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