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不可切除结直肠癌肝转移的肝移植：一线生机。

Liver transplantation for non-resectable colorectal liver metastases: the thin red line.

机构信息

Department of Gastrointestinal Surgery, Stavanger University Hospital, Stavanger, Norway.

Gastrointestinal Translational Research Unit, Stavanger University Hospital, Stavanger, Norway.

出版信息

Br J Cancer. 2023 May;128(10):1794-1796. doi: 10.1038/s41416-023-02234-w. Epub 2023 Mar 23.

DOI:10.1038/s41416-023-02234-w
PMID:36959377
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10147914/
Abstract

Transplantation for non-resectable colorectal liver metastasis (CRLM) has become accepted for a few, select patients following stringent criteria. With improved understanding of the selective indications, enhanced curation of the donor pool, and by further insight into cancer biology, novel avenues for research may be developed and eventually benefit more patients with non-resectable CRLM.

摘要

对于少数符合严格标准的特定患者，不可切除的结直肠癌肝转移（CRLM）的移植已被接受。随着对选择性适应症的深入了解、供体库的精心管理以及对癌症生物学的进一步了解，可能会开发出新的研究途径，并最终使更多不可切除的 CRLM 患者受益。

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本文引用的文献

1
Metabolic tumor volume predicts long-term survival after transplantation for unresectable colorectal liver metastases: 15 years of experience from the SECA study.代谢肿瘤体积可预测不可切除结直肠癌肝转移患者移植后的长期生存：SECA 研究 15 年经验。
Ann Nucl Med. 2022 Dec;36(12):1073-1081. doi: 10.1007/s12149-022-01796-8. Epub 2022 Oct 14.
2
Regional Therapy for Colorectal Cancer Liver Metastases: Which Modality and When?结直肠癌肝转移的区域治疗：哪种方式，何时？
J Clin Oncol. 2022 Aug 20;40(24):2806-2817. doi: 10.1200/JCO.21.02505. Epub 2022 Jun 1.
3
Predicting 10-year survival after resection of colorectal liver metastases; an international study including biomarkers and perioperative treatment.预测结直肠肝转移切除术后 10 年生存率：一项包含生物标志物和围手术期治疗的国际研究。
Eur J Cancer. 2022 Jun;168:25-33. doi: 10.1016/j.ejca.2022.01.012. Epub 2022 Apr 14.
4
Liver transplantation for non-resectable colorectal liver metastases: the International Hepato-Pancreato-Biliary Association consensus guidelines.不可切除结直肠肝转移的肝移植：国际肝胆胰协会共识指南。
Lancet Gastroenterol Hepatol. 2021 Nov;6(11):933-946. doi: 10.1016/S2468-1253(21)00219-3. Epub 2021 Sep 8.
5
Ex situ machine preservation of donor livers for transplantation: HOPE for all?供体肝脏的体外机器保存用于移植：是否有希望适用于所有人？
Br J Surg. 2021 Oct 23;108(10):1139-1141. doi: 10.1093/bjs/znab293.
6
Addressing the variation in hepatic surgery for colorectal liver metastasis.解决结直肠癌肝转移肝切除术的差异问题。
Hepatobiliary Surg Nutr. 2021 Jan;10(1):103-106. doi: 10.21037/hbsn.2020.04.07.
7
Choices of Therapeutic Strategies for Colorectal Liver Metastases Among Expert Liver Surgeons: A Throw of the Dice?专家肝脏外科医师治疗结直肠肝转移的策略选择：掷骰子？
Ann Surg. 2020 Nov;272(5):715-722. doi: 10.1097/SLA.0000000000004331.
8
Frontiers in liver transplantation.肝脏移植前沿
Br J Surg. 2020 Jun;107(7):790-792. doi: 10.1002/bjs.11714.
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Prognostic Factors Change Over Time After Hepatectomy for Colorectal Liver Metastases: A Multi-institutional, International Analysis of 1099 Patients.结直肠癌肝转移切除术后预后因素随时间变化：1099 例多机构、国际分析。
Ann Surg. 2019 Jun;269(6):1129-1137. doi: 10.1097/SLA.0000000000002664.
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Deciphering the Molecular Code to Colorectal Liver Metastasis Biology Through Microsatellite Alterations and Allelic Loss: The Good, the Bad, and the Ugly.通过微卫星改变和等位基因缺失解读结直肠癌肝转移生物学的分子密码：好的、坏的与丑陋的
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