Department of Surgery, Section of Hepatobiliary Surgery and Liver Transplantation, University of Groningen, University Medical Centre Groningen, Groningen, the Netherlands.
Br J Surg. 2021 Oct 23;108(10):1139-1141. doi: 10.1093/bjs/znab293.
Hypothermic oxygenated machine perfusion (HOPE) reduces ischaemia–reperfusion injury of donor livers and thereby improves outcomes after transplantation. End-ischaemic normothermic machine perfusion (NMP) enables assessment of hepatobiliary viability and selection of livers that would otherwise have been declined for transplantation. We advocate the combined use of (dual) HOPE and NMP for livers that are considered high risk, but may still be transplanted safely after resuscitation and assessment of hepatobiliary viability. Combined dual HOPE–NMP has the potential to substantially decrease the high rates of deceased donor liver discard.
低温氧合机器灌注（HOPE）可减少供肝的缺血再灌注损伤，从而改善移植后的效果。终末期常温机器灌注（NMP）可评估肝胆功能的存活情况，并选择原本会因移植而被拒绝的肝脏。我们主张将（双）HOPE 和 NMP 联合用于高危肝脏，但在复苏和评估肝胆功能存活后，仍可安全移植。联合使用双 HOPE-NMP 有可能大大降低高比例的已故供肝废弃率。
