后疫情时代重振癌症临床试验：是时候进行改革了。
Revitalising cancer trials post-pandemic: time for reform.
机构信息
Department of Medical Oncology, Guy's & St Thomas NHS Foundation Trust, London, UK.
Institute of Cancer Policy, King's College London, London, UK.
出版信息
Br J Cancer. 2023 Apr;128(8):1409-1414. doi: 10.1038/s41416-023-02224-y. Epub 2023 Mar 23.
Abstract
The COVID-19 pandemic posed significant risk to the health of cancer patients, compromised standard cancer care and interrupted clinical cancer trials, prompting dramatic streamlining of services. From this health crisis has emerged the opportunity to carry forward an unexpected legacy of positive reforms to clinical cancer research, where conventionally convoluted approvals processes, inefficient trial design, procedures and data gathering could benefit from the lessons in rationalisation learned during the pandemic.
摘要
COVID-19 大流行给癌症患者的健康带来了重大风险，影响了标准的癌症治疗并中断了临床癌症试验，促使服务大幅简化。这场卫生危机带来了一个意想不到的机会，可以将临床癌症研究中的积极改革延续下去，在这些研究中，传统上复杂的审批流程、效率低下的试验设计、程序和数据收集都可以从大流行期间学到的合理化经验中受益。
相似文献
1
Revitalising cancer trials post-pandemic: time for reform.后疫情时代重振癌症临床试验：是时候进行改革了。
Br J Cancer. 2023 Apr;128(8):1409-1414. doi: 10.1038/s41416-023-02224-y. Epub 2023 Mar 23.
2
Clinical Evidence Generation During a Pandemic: Lessons Learned for Sustaining Progress.大流行期间的临床证据生成：持续进展的经验教训。
Cancer J. 2022;28(2):151-156. doi: 10.1097/PPO.0000000000000589.
3
The Enduring Effects of COVID for Cancer Care: Learning from Real-Life Clinical Practice.新冠疫情对癌症护理的持久影响：从现实临床实践中学习。
Clin Cancer Res. 2023 May 1;29(9):1670-1677. doi: 10.1158/1078-0432.CCR-23-0151.
4
The impact of COVID-19 on the interpretation of psycho-oncological support trial results: a quasi-experimental approach using the data from the new form of care "Integrated cross-sectoral psycho-oncology (nFC-isPO)".COVID-19 对心理肿瘤学支持试验结果解读的影响：采用“跨部门整合心理肿瘤学（nFC-isPO）”新护理形式数据的准实验方法。
BMC Health Serv Res. 2023 May 30;23(1):556. doi: 10.1186/s12913-023-09544-y.
5
Impact of COVID-19 on the Organization of Cancer Care in Belgium: Lessons Learned for the (Post-)Pandemic Future.新冠疫情对比利时癌症护理组织的影响：为（后）疫情时代吸取的教训。
Int J Environ Res Public Health. 2022 Sep 30;19(19):12456. doi: 10.3390/ijerph191912456.
6
Lessons From the Impact of the COVID-19 Pandemic at the National Cancer Institute: Cancer Research and Care.从 COVID-19 大流行对美国国家癌症研究所的影响中吸取的教训：癌症研究与护理。
Cancer J. 2022;28(2):118-120. doi: 10.1097/PPO.0000000000000584.
7
Pandemic preparedness and response regulations in Finland: Experiences and implications for post-COVID-19 reforms.芬兰的大流行准备和应对法规：经验及对 COVID-19 后改革的启示。
Health Policy. 2023 Jun;132:104802. doi: 10.1016/j.healthpol.2023.104802. Epub 2023 Mar 31.
8
Frontline Physician Perspectives on Their Experiences Working During the First Wave of the COVID-19 Pandemic.一线医生对其在 COVID-19 大流行第一波期间工作经历的看法。
J Gen Intern Med. 2022 Dec;37(16):4233-4240. doi: 10.1007/s11606-022-07792-y. Epub 2022 Sep 19.
9
Navigating Cancer Care in the COVID-19 Era.在新冠疫情时代的癌症护理
Cancer Discov. 2022 Feb;12(2):283. doi: 10.1158/2159-8290.CD-ND2021-0116. Epub 2021 Dec 9.
10
Advancing Health Equity in Cancer-Related Distress: Lessons Learned From the COVID-19 Pandemic on Leveraging Digital Tools and Future Directions.推进癌症相关痛苦中的健康公平：从新冠疫情中汲取的关于利用数字工具的经验教训及未来方向
J Natl Compr Canc Netw. 2022 Jul;20(7):850-852. doi: 10.6004/jnccn.2022.7043.
引用本文的文献
1
Changes in clinical presentation, management, and survival outcomes in patients affected by colorectal cancer following COVID-19 pandemic.2019年冠状病毒病大流行后受结直肠癌影响患者的临床表现、管理及生存结果的变化
Oncologist. 2024 Nov 26. doi: 10.1093/oncolo/oyae310.
2
Quantifying the impact of the COVID-19 pandemic on cancer center clinical trial operations.量化 COVID-19 大流行对癌症中心临床试验运作的影响。
JNCI Cancer Spectr. 2023 Jul 3;7(4). doi: 10.1093/jncics/pkad048.
本文引用的文献
1
Association of Remote Technology Use and Other Decentralization Tools With Patient Likelihood to Enroll in Cancer Clinical Trials.远程技术使用和其他分散工具与患者参与癌症临床试验的可能性的关联。
JAMA Netw Open. 2022 Jul 1;5(7):e2220053. doi: 10.1001/jamanetworkopen.2022.20053.
2
Real-World Evidence - Where Are We Now?真实世界证据——我们目前处于什么阶段？
N Engl J Med. 2022 May 5;386(18):1680-1682. doi: 10.1056/NEJMp2200089. Epub 2022 Apr 30.
3
Federated Networks for Distributed Analysis of Health Data.用于健康数据分布式分析的联邦网络。
Front Public Health. 2021 Sep 30;9:712569. doi: 10.3389/fpubh.2021.712569. eCollection 2021.
4
Cancer Clinical Trial Participation at the 1-Year Anniversary of the Outbreak of the COVID-19 Pandemic.癌症临床试验参与在 COVID-19 大流行爆发一周年之际。
JAMA Netw Open. 2021 Jul 1;4(7):e2118433. doi: 10.1001/jamanetworkopen.2021.18433.
5
Telehealth in Oncology: ASCO Standards and Practice Recommendations.肿瘤学中的远程医疗：ASCO 标准和实践建议。
JCO Oncol Pract. 2021 Sep;17(9):546-564. doi: 10.1200/OP.21.00438. Epub 2021 Jul 28.
6
Trends in Oncology Clinical Trials Launched Before and During the COVID-19 Pandemic.肿瘤学临床试验在 COVID-19 大流行之前和期间启动的趋势。
JAMA Netw Open. 2021 Jan 4;4(1):e2036353. doi: 10.1001/jamanetworkopen.2020.36353.
7
Survey of the Impact of COVID-19 on Oncologists' Decision Making in Cancer.COVID-19对肿瘤学家癌症决策影响的调查
JCO Glob Oncol. 2020 Aug;6:1248-1257. doi: 10.1200/GO.20.00300.
8
Managing cancer patients during the COVID-19 pandemic: an ESMO multidisciplinary expert consensus.《COVID-19 大流行期间的癌症患者管理：ESMO 多学科专家共识》
Ann Oncol. 2020 Oct;31(10):1320-1335. doi: 10.1016/j.annonc.2020.07.010. Epub 2020 Jul 31.
9
The National Lung Matrix Trial of personalized therapy in lung cancer.国家肺癌矩阵试验：肺癌个体化治疗。
Nature. 2020 Jul;583(7818):807-812. doi: 10.1038/s41586-020-2481-8. Epub 2020 Jul 15.
10
Telemedicine During the COVID-19 Pandemic: Impact on Care for Rare Cancers.新冠疫情期间的远程医疗：对罕见癌症护理的影响
JCO Glob Oncol. 2020 Jul;6:1046-1051. doi: 10.1200/GO.20.00220.
Zotero 插件